β-葡聚糖对含糖大输液细菌内毒素检查的影响  

Percutaneous transsplenic varices embolization to treat upper gastrointestinal bleeding

作　　者：叶良君 张强[2] 张涛 贺利成 

机构地区：[1]武警湖南总队机关门诊部,湖南长沙410008 [2]武警湖南总队卫生处,湖南长沙410008

出　　处：《中国药业》2008年第19期24-25,共2页China Pharmaceuticals

摘　　要：目的考察β-葡聚糖对含糖大输液细菌内毒素检查的影响。方法以普通鲎试剂、特异性鲎试剂分别与不同浓度和同浓度不同位置的含糖大输液进行凝胶试验。结果含糖大输液与普通鲎试剂的凝胶试验阳性反应率较高,而且糖浓度越高、装量越大,阳性反应率越高,且受取样位置的影响。结论为排除β-葡聚糖对含糖大输液细菌内毒素检查的干扰,建议使用特异性鲎试剂,同时应对药典中有关葡萄糖原料的质量标准和细菌内毒素检查法的规定加以修订。Objective To evaluate the value of percutaneous transsplenic varices embolization (PTSVE) to treat upper gastrointestinal bleeding. Methods Twelve cases of upper gastrointestinal bleeding underwent PTSVE with harderners and coil. All of them were with liver cirrhosis and portal hypertension. 2 patients were complicated with thrombus block portal vein.10 patients were suffered hepatic cell carcinoma(HCC). Among the HCC patients, 4 had large mass in right lobe, 6 had embolus of cancer blocking portal vein. These cases were not suitable for percutaneous transhepatic varices embolization(PTHVE). Percutaneous transsplenic portal catheterization and angiography were performed under the guidance of fluoroscopy. After selective catheterization, esophageal varices were embolized using harderner(absolute alcohol or sodium morrhuate) and coil, totally 23 esoph-ageal varices were embolized. Four stents were put in portal vein of the 4 embolus of cancer cases. Results Technical success were achieved in all patients. Upper gastrointestinal bleeding stopped and there was no recur within 1 month follow up. No serious complications were observed. Conclusion PTSVE is safe and efficient for the treatment of upper gastrointestinal bleeding. It is an alternative of PTHVE , especially in cases with portal vein occlusion or large mass HCC in right lobe of liver.

关 键 词：Β-葡聚糖 含糖大输液 细菌内毒素检查 普通鲎试剂 特异性鲎试剂 

分 类 号：R927.12[医药卫生—药学] R977.7