977例异常孕产史夫妇的染色体核型分析  

Study on chromosome karyotype of 977 cases with abnormal pregrancy-labor history

作　　者：付先虎[1] 陈汉平[1] 吴行飞[1] 唐红菊[1] 吕莉娟[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,湖北武汉430030

出　　处：《中国妇幼保健》2008年第28期4022-4024,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨异常孕产史夫妇与染色体核型异常的关系。方法:对977例异常孕产史夫妇进行外周血淋巴细胞培养及染色体核型分析。结果:染色体异常核型52例,染色体异常率为5.32%,其中,平衡异位26例,倒位13例,多态性变异11例,分别占染色体异常核型的50%、25%和21.2%。结论:染色体核型异常是导致异常孕产史的重要原因之一,对异常孕产史夫妇进行细胞遗传学检查十分必要。Objective： To analyze the relationship between abnormal chromosome karyotype and abnormal pregnancy -labor history. Methods： Peripheral blood sample from 977 cases with abnormal pregnancy - labor history was coUeeted. Then the chromosomal was analyzed through the culture of peripheral blood lymphocyte and G - dominance band of the chromosome. Results： Totally abnormal chromosome karyotype were showed in 52 cases. The total incidence of chromosomal abnormalities was 5. 32%. Conclusion： The chromosome karyotype abnormality is one of the most important reasons of abnormal pregnarncy - labor history. It is necessary for couples with abnormal pregnancy - labor history to take chromosome examination.

关 键 词：异常孕产史 染色体异常 细胞遗传学 

分 类 号：R596[医药卫生—内科学] R714[医药卫生—临床医学]