The entropy characters of point mutation  

作　　者：MA GuoJi LIANG LiJing FAN YanHui WANG WenJuan DAI JiaQing YUAN ZhiFa 

机构地区：[1]College of Science, Northwest A&F University, Yangling 712100, China [2]Bioinformatics Center, Northwest A&F University, Yangling 712100, China [3]College of Life Sciences, Northwest A&F University, Yangling 712100, China

出　　处：《Chinese Science Bulletin》2008年第19期3008-3015,共8页

摘　　要：The biological diversity, which depends on the genetic material DNA, is the foundation for a species to survive and evolve. The entropy is the best measurement of biological diversity. Based on the sin-gle-parameter and the two-parameter models, here we established some differential equations about the point mutation of a DNA sequence with finite length, as well as some functions describing the processes of the variation in quantities of 4 kinds of bases (A, T, G and C) in the DNA sequence. At the molecular level, we discussed the entropy characteristics of point mutation. The results proved that a species maintained its entropy and evolved in the direction of the increasing biological diversity. In order to testify the theoretical results, we did a series of computer simulations of random point muta- tion in Matlab environment. The results were well consistent with the theoretical researches.The biological diversity, which depends on the genetic material DNA, is the foundation for a species to survive and evolve. The entropy is the best measurement of biological diversity. Based on the single-parameter and the two-parameter models, here we established some differential equations about the point mutation of a DNA sequence with finite length, as well as some functions describing the processes of the variation in quantities of 4 kinds of bases （A, T, G and C） in the DNA sequence. At the molecular level, we discussed the entropy characteristics of point mutation. The results proved that a species maintained its entropy and evolved in the direction of the increasing biological diversity. In order to testify the theoretical results, we did a series of computer simulations of random point mutation in Matlab environment. The results were well consistent with the theoretical researches.

关 键 词：基因突变 信息处理 生物多样化 实验研究 

分 类 号：R318[医药卫生—生物医学工程]