AG825 increases radiosensitivity of breast cancer cell  

AG825对乳腺癌细胞的辐射增敏作用(英文)

作　　者：Bo Luo Shiying Yu Liang Zhuang Shu Xia Zhen Zhao Lei Rong 

机构地区：[1]Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2008年第10期587-589,共3页中德临床肿瘤学杂志（英文版）

基　　金：a grant from the National Natural Science Foundation of China(No.30672426)

摘　　要：Objective:To observe the radiosensitivity effect of AG825 on breast cancer cell line with high expression of ERBB2 in vitro.Methods:MTT and clone formation assay were used to observe the effect of AG825 on proliferation and radiosensitivity of breast cancer line MDA-MB-453.After MDA-MB-453 was exposed to AG825 and radiation,comet assay and Western blotting were applied to detect double strand break and expressions DNA-PKcs protein,respectively.Results:AG825 inhibited proliferation rate and decrease survival fraction of MDA-MB-453.After radiation,compared with control group,expression of DNA-PKcs was lower in group with AG825 presence but double strand break was higher.Conclusion:AG825 could increase radiosensitivity of breast cancer cell line MDA-MB-453,and it may associate with its inhibition of radiation induced expression of DNA-PKcs and double strand break repair.

关 键 词：AG825 breast carcinomas RADIOSENSITIVITY 

分 类 号：R737.9[医药卫生—肿瘤]