PAS综合疗法对兔动脉粥样硬化病变的干预  

Effects of PAS United Therapy on Atherogenesis of Rabbits Model

作　　者：王素香[1] 王拥军[1] 尹洪超[2] 梁宪红[1] 卫景沛[3] 林金嬉[1] 梁德君[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经内科,北京市100050 [2]中国医学科学院基础医学研究所病理学系,北京市100005 [3]航空工业中心医院神经内科,北京市100012

出　　处：《中国动脉硬化杂志》2008年第8期628-632,共5页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨普罗布考抗氧化、氯吡格雷抗血小板制剂、阿托伐他汀联合用药对兔动脉粥样硬化病变的干预作用。方法新西兰雄性大白兔36只随机分为4组,分别给予正常饮食及高脂饮食6周后高脂组再分为3组:高脂组,高脂+阿托伐他汀2.5 mg/(kg.d)组,高脂+普罗布考(1.0 g/d)+氯吡格雷5 mg/(kg.d)+阿托伐他汀2.5 mg/(kg.d)PAS组,继续喂养4周后观察主动脉动脉粥样硬化斑块形成情况,分别采用HE染色和免疫组织化学染色观察斑块部位内膜病变程度和炎症细胞的表达。结果高脂组主动脉有粥样硬化病变形成,病变内有大量巨噬细胞聚集。阿托伐他汀和PAS组动脉粥样硬化病变明显减轻,斑块部位内膜面积和厚度下降,巨噬细胞数量显著减少,与高脂组比较差异具有显著性(P<0.01),联合治疗组优于阿托伐他汀组(P<0.05)。结论抗氧化、抗血小板、他汀联合用药对动脉粥样硬化斑块的形成和炎症具有明显的干预作用,其作用优于单纯使用阿托伐他汀,说明联合治疗对于稳定斑块、以及干预缺血事件的发生较单纯使用他汀类药物更具有临床应用的意义。Aim To study the effect of united therapy of probueol （P） and elopidogrel （Anti-thrombosis, A） and atorvastatin （statin,S） on rabbit athemgenesis. Methods 36 rabbits were randomized into four groups. The one group did not receive treatments and served as control group. Atherosclerosis was induced in the aorta arteries of rabbits by athemgenic diet in the next groups for 6 weeks. Then, animals were randomized to receive either no treatment or therapy. One group of treatment were received atorvastafin 2.5 mg/ （ kg· d）, and the other accepted probucol（ 1.0 g/d） and clopidogrel 5 mg/ （ kg· d ） and atorvastatin 2.5 rag/ （kg· d） and killed after 4 weeks. Results Atorvastatin and united therapy induced a significant reduction in serum lipids and in lesion size, also were the area and thickness in neointima. Arterial macrophage infiltration was abolished by the treatment. Notedly, there was a more evident effect in united therapy than Atorvastafin in anti-atherosclerosis. Conclusions Atorvastatin and united therapy diminish the plaque lesion and neointimal itfflammation in rabbit atheroseleresis model, and the effect of united therapy was more than atorvastafin. Tiffs eould eontribute to the more stabilization of the atherosclertic plaque, and may be a more meaning additional prediefion for the reduction of acute isehemie events in patients treated with united therapy.

关 键 词：病理学与病理生理学 动脉粥样硬化 巨噬细胞 普罗布考 氯吡格雷 阿托伐他汀 

分 类 号：R363[医药卫生—病理学]