Adipostatin A的简易合成  

Facile Total Synthesis of Adipostatin A

作　　者：杨丽娟[1] 武利强[1] 杨春广[1] 

机构地区：[1]新乡医学院药学院,河南新乡453003

出　　处：《河南职工医学院学报》2008年第5期429-431,共3页Journal of Henan Medical College For Staff and Workers

摘　　要：目的用简易方法合成Adipostatin A。方法以3,5-二甲氧基溴苯为原料,经金属化、偶联、脱甲基化反应制得Adipostatin A。结果成功地合成了Adipostatin A,总收率为64%。目标化合物的结构经核磁共振氢谱及元素分析确证。结论本法合成步骤短,反应条件温和,收率较高。Objective To synthesize Adipostatin A by an improved synthetic method. Methods Adipostatin A was synthesized from 3,5-dimethoxybromobenzene through three steps： metallation with Mg, coupling, with （Z）-1- bromo-8-pentadecane in the presence of Li2CuCl4-THF, demethylation with MeMgI. Results Adipostatin A was synthesized successfully in the total yield of 64%. The structure of the target compound was confirmed by 1H-NMR and elemental analysis. Conclusion This synthetic technique is simple, convenient and effective.

关 键 词：Adipostatin A 3 5-二甲氧基溴苯 偶联 合成 

分 类 号：R914.5[医药卫生—药物化学]