MELAS综合征的MRI表现  

MRI Manifestations of MELAS Syndrome

作　　者：修建军[1] 李传福[2] 张金山[1] 曾庆师[2] 谷涛[3] 

机构地区：[1]解放军总医院放射科,北京100853 [2]山东大学齐鲁医院影像中心 [3]卫生部北京医院放射科

出　　处：《实用放射学杂志》2008年第10期1317-1319,共3页Journal of Practical Radiology

摘　　要：目的探讨MELAS综合征的MRI表现特点。方法对13例MELAS综合征患者的临床与影像学资料进行回顾性分析。结果MRI表现为长T1长T2信号,多位于颞、顶、枕叶皮层,病变形态、大小、范围易变,呈游走性,多灶性,不按血管支配区分布。MRA没有大血管闭塞。常见基底节钙化,伴脑室扩大和脑萎缩。DWI病变多表现为ADC值升高。病灶MRS检查可见Lac峰。结论MELAS综合征的影像学表现具有一定特点,根据临床及影像学特点,结合肌肉活检可对该病做出正确诊断。Objective To investigate MR imaging characteristics of MELAS syndrome.Methods The clinical data and MRI features of 13 cases with MELAS syndrome were retrospectively analyzed.Results Multiple hypointense on T1WI and hyperintense on T2WI lesions were showed predominantly in the gray matter of the temporal, parietal and occipital lobes. The lesions crossed vascular boundaries. No stenosis and occlusion of main artery were displayed by MRA.Basal ganglia calcifications and cerebral atrophy with widening of ventricles were also frequent found. Increased ADC value of the leison on DWI and appearance of Lac peak on ^1H-MRS were useful in diagnosis.Conclusion There are some characteristics of MRI in patients with MELAS syndrome.Combined clinical informations with neuroimaging and muscle biopsy, the diagnosis of MELAS syndrome can be made correctly.

关 键 词：脑 MELAS综合征 线粒体脑肌病 磁共振成像 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]