冬枣提取物对S_(180)荷瘤小鼠的抗氧化作用研究  

Study on Antioxidant Activity of DJE on S_(180) Tumor-Bearing Mice

作　　者：马莉[1] 胡迎芬[1] 马爱国[1] 张秀珍[1] 梁惠[1] 孙永叶[1] 衣学梅[1] 

机构地区：[1]青岛大学医学院,山东青岛266021

出　　处：《青岛大学学报（工程技术版）》2008年第3期30-34,共5页Journal of Qingdao University(Engineering & Technology Edition)

摘　　要：为观察冬枣提取物(Dongzao Jujube Extract,DJE)对S180荷瘤小鼠的抗氧化作用,建立了S180荷瘤小鼠模型,给予DJE灌胃后观察其肿瘤生长情况,测定血浆中超氧化物歧化酶(SOD)的活力、丙二醛(MDA)的含量及红细胞溶血度。结果显示:DJE可明显抑制S180荷瘤小鼠瘤体的生长,肿瘤抑制率最高达到24.8%;可明显升高小鼠血浆中SOD酶的活力;可降低血浆中MDA的含量以及红细胞的溶血度。This study is to observe the antioxidative activity of Dongzao Jujube Extract （DJE） on S180 Tumor-bearing mice. The effect of DJE on tumor weight was observed by establishing the S180-bearing mice model after DJE was given orally. Superoxide dismutase （SOD） activity, malondialdehyde （MDA） level in plasma and hemolytic degree of RBC were measured respectively. Results showed that DJE could significantly inhibit the growth of S180 tumor in mice, and the highest inhibitory rate was up to 24.8%. Furthermore, it could significantly increase activity of SOD, and decrease content of MDA and hemolytic degree of RBC.

关 键 词：冬枣 S180 荷瘤小鼠 超氧化物歧化酶(SOD) 丙二醛(MDA) 红细胞溶血度 

分 类 号：R73-36[医药卫生—肿瘤]