CDK2及其抑制因子P57^(kip2)在血管瘤中的表达和意义  

Expression of Cyclin-Dependent Kinase 2 and P57^(kip2) in Human Dermal Hemangiomas

作　　者：刘平[1,2] 张端莲[1] 汤显斌[2] 

机构地区：[1]武汉大学医学院人体解剖与组织胚胎学系,湖北武汉430071 [2]郧阳医学院附属太和医院病理科,湖北十堰442000

出　　处：《武汉大学学报（医学版）》2008年第6期716-719,I0001,共5页Medical Journal of Wuhan University

基　　金：国家自然科学基金(编号:30271345);湖北省科技厅资助项目(编号:2003ABA164);湖北省卫生厅资助项目(编号:JXIB075)

摘　　要：目的:探讨细胞周期素依赖性激酶2(CDK2)及其抑制因子P57kip2在血管瘤发生、发展过程中的表达及意义。方法:应用免疫组织化学方法(SP法)检测人皮肤血管瘤增生期、退化期及其正常皮肤组织中CDK2及P57kip2的表达水平。结果:CDK2在增生期血管瘤内皮细胞的表达明显高于退化期血管瘤内皮细胞和正常皮肤组织血管内皮细胞(P<0.001),而后两组比较差异无统计学意义。P57kip2在增生期血管瘤内皮细胞的表达显著低于退化期血管瘤内皮细胞(P<0.005),退化期血管瘤内皮细胞P57kip2表达水平与正常组织相比,差异有统计学意义(P<0.05)。结论:CDK2的高表达及P57kip2的低表达或缺失可能在血管瘤的发生发展中起重要作用。Objective： To investigate the expression and significance of cyclin-dependent kinase 2 （CDK2） and its inhibitor P57kip2 in the occurrence, development and regression of human hemangiomas. Methods： The expression of CDK2 and P57kip2 was investigated by using immunohistochemical technique in proliferating, involuting human hemangiomas and normal skin tissues. Results： The expression of CDK2 was significantly higher in proliferating hemangiomas than in involuting hemangomas and normal skin tissues （P〈0. 001）, and there was no significant difference in CDK2 staining between involuting hemangomas and normal skin tissues. The expression of P57kip2 was significantly lower in proliferating hemangiomas than in involuting hemangomas tissues （P〈0. 005）, and was significantly lower in the involuting hemangiomas than in normal skin tissues （P〈0.05）. Conclusion： The increased expression of CDK2 and the decreased expression or loss of P57kip2 may play an important role in the occurrence, development and regression of human hemangiomas.

关 键 词：血管瘤 内皮细胞 细胞周期素依赖性激酶2 P57^KIP2 

分 类 号：R732.2[医药卫生—肿瘤]