奥沙利铂、5-氟尿嘧啶、亚叶酸钙术前联合治疗局部进展期直肠癌的效果比较  

Treatment of progressing rectal cancer with Oxaliplatin,5-Fluorouracil and Calcium Folinate

作　　者：周彬 刘南[2] 付强[3] 李辉[4] 

机构地区：[1]兰州军区临潼疗养院疗养八科,陕西西安710060 [2]解放军451医院神经内科,陕西西安710054 [3]陕西中医学院,陕西咸阳712083 [4]第四军医大学航空生理学教研室,陕西西安710033

出　　处：《第四军医大学学报》2008年第18期1709-1711,共3页Journal of the Fourth Military Medical University

摘　　要：目的：了解奥沙利铂、5-氟尿嘧啶（5-FU）、亚叶酸钙新辅助化疗方案治疗局部进展期直肠癌的疗效和毒副作用.方法：局部进展期直肠癌患者144例,术前接受的新辅助化疗方案65例：奥沙利铂120mg/m2（d1）,5-FU500（mg/m2·d）（d1～5）,亚叶酸钙100mg/（m2·d）（d1~5）静滴,1/d,共5d.观察新辅助化疗后肿瘤原发病灶的缓解情况,并观察新辅助化疗的毒副反应.结果：新辅助化疗后65例进行了根治性手术,其中完全缓解（CR）15.4%,部分缓解（PR）63.0%,病理完全缓解（pCR）75.4%.常规手术组79例,CR10.1%,PR45.7%,pCR59.5%.新辅助化疗组与常规手术组相比有差异（P〈0.05）,毒副反应主要为白细胞减少症、恶心、脱发,但未有因此而发生的败血症和死亡病例.结论：应用奥沙利铂、5-FU、亚叶酸钙新辅助化疗方案治疗进展期直肠癌疗效显著,耐受性良好.AIM： To evaluate the clinical effect of the neoadjuvant chemotherapy with oxaliplatin, 5-fluorouracil （ 5-FU ） and calcium folinate on the treatment of progressing carcinoma of rectum. METHODS： Among 144 patients with progressing carcinoma of rectum,65 cases received neoadjuvant chemotherapy before operation including oxaliplatin 120 mg/m2 （day 1 ）,5-fluorouracil 500 mg/m2 （ day 1 to 5 ） and calcium folinate 100 mg/m2 （ day 1 to 5 ）. The response in the tumor and the chemotherapy toxicity were observed for each patient. RESULTS： The complete remission（CR） was 15.4%, partial remission （PR） 63.0%, and pathological complete remission （ pCR ） 75.4% in neoadjuvant chemotherapy group, and which were 10. 1% ,45.7%, 59.5% respectively in routine operation group. There was significant difference between neoadjuvant chemotherapy and routine operation groups（ P 〈 0.05 ）. The common toxicities were leukocytopenia, nausea and alopecia. CONCLUSION： The neoadjuvant chemotherapy with oxaliplatin, 5-FU and calcium Folinate is a very effective and well-tolerated regimen for carcinoma of rectum.

关 键 词：直肠肿瘤 化学疗法 辅助 临床疗效 

分 类 号：R73[医药卫生—肿瘤]