Synthesis and antitumor activity of N^1-acetylamino-(5-alkyl/aryl-1,3,4-thiadiazole-2-yl)-5-fluorouracil derivatives  

作　　者：Kai Bo Zheng Jun He Jie Zhang 

机构地区：[1]College of Chemistry, Sichuan University, Chengdu 610064, China [2]Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China

出　　处：《Chinese Chemical Letters》2008年第11期1281-1284,共4页中国化学快报（英文版）

摘　　要：A new series of N^1-acetylamino-（5-alkyl/aryl- 1,3,4-thiadiazole-2-yl）-5-fluorouracil derivatives were designed and synthesized. These compounds have not been reported in literature, and their structure chemical were confirmed by IR, ^1H NMR and MS （HRMS）. The results of antitumor inhibitory activity test showed that some compounds possess more potent antitumor inhibitory activity than 5-fluorouracil.A new series of N^1-acetylamino-（5-alkyl/aryl- 1,3,4-thiadiazole-2-yl）-5-fluorouracil derivatives were designed and synthesized. These compounds have not been reported in literature, and their structure chemical were confirmed by IR, ^1H NMR and MS （HRMS）. The results of antitumor inhibitory activity test showed that some compounds possess more potent antitumor inhibitory activity than 5-fluorouracil.

关 键 词：5-Fluorouracil derivatives 1 3 4-THIADIAZOLE SYNTHESIS ANTITUMOR 

分 类 号：TQ463[化学工程—制药化工]