大肠癌区域动静脉血氨基酸的研究  

THE EXTRACTION RATE OF AMINO ACIDS BY NORMAL AND TUMOR TISSUE OF COLON

作　　者：王林波[1] 张苏展[1] 丁克峰[1] 郑树[1] 

机构地区：[1]浙江医科大学附属第二医院肿瘤科

出　　处：《浙江医科大学学报》1997年第3期114-117,共4页

基　　金：八五攻关课题

摘　　要：本实验选用16例病理学证实的大肠癌患者。手术中抽取患者肠系膜动脉血（A），并分别抽取大肠癌处回流静脉血（C）及邻近正常大肠的系膜静脉血（E）。用氨基酸自动分析仪测定A、C、E中游离氨基酸浓度，再将各种氨基酸浓度换算成大肠癌区域动静脉血氨基酸提取率（R1）及正常大肠组织区域动静脉血氨基酸摄取率（R2）。结果：①大肠癌区域动静脉血或基酸提取率明显高于正常大肠区域动静脉血氨基酸提取率（P＜0．01）。②大肠癌区域动静脉血氨基酸提取率与肿瘤大小关系不明显，与分期关系不大（仅蛋氨酸的P＜0．05）。Sixteen cases of colonic cancer were studied in the experiment. The blood samples were takenfrom the mesenterica superior arteria or mesenterica inferior arteria(sample A),from the venulaof colonic cancer (sample C) and from the venula of normal colonic edge (sample E)during theoperation for each. All samples(A,C,E)were analyzed for amino acids pattern by automated ionexchange chromatography. The extraction rates of amino acids were calculated as R1 {R1= [(A-C )/A]×100%} and normal colonic edge as R2{R2 = [(A - E)/A]×100%}. The t-test wasused for statistics. The results were as follows: ①R1 was higher than R2(P<0. 01,except methionine). ②There were no statistical difference between R1 of Dukes'B tumor and that of Dukes'Cand D and between those of difference tumor sizes.

关 键 词：大肠肿瘤 氨基酸 动脉血 静脉血 

分 类 号：R735.340.2[医药卫生—肿瘤] R362[医药卫生—临床医学]