新疆地区汉、维两民族口腔扁平苔藓患者HLA Ⅱ-DRB1等位基因的检测与比较  

Study on the association between HLA Ⅱ-DRB1 alleles and oral lichen planus between Han Chinese and Uygur people in Xinjiang Uygur Autonomous Region

作　　者：凌彬[1] 龚忠诚[1] 刘奕杉[2] 林兆全[1] 王善征[3] 王星[4] 

机构地区：[1]新疆医科大学第一附属医院口腔颌面外科,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院口腔科,新疆乌鲁木齐830054 [3]新疆医科大学第一附属医院输血科,新疆乌鲁木齐830054 [4]新疆医科大学第一附属医院医学研究中心,新疆乌鲁木齐830054

出　　处：《中国口腔颌面外科杂志》2008年第6期458-461,共4页China Journal of Oral and Maxillofacial Surgery

摘　　要：目的:对新疆地区汉、维两民族口腔扁平苔藓(OLP)患者的人类白细胞抗原HLAⅡ-DRB1等位基因进行检测与分析。方法:采用聚合酶链反应-序列特异性引物(PCR-SSP)技术,对34例汉族、14例维吾尔族OLP患者和123例汉族、42例维吾尔族正常对照进行HLAⅡ-DRB1等位基因表现频率的检测,采用SPSS16.0软件包对两组间等位基因频率进行χ2检验和Fisher确切概率检验。结果:汉族OLP组HLAⅡ-DRB1*11等位基因表现频率(23.53%)高于正常对照组(9.76%),HLAⅡ-DRB1*12等位基因表现频率(5.88%)低于正常对照组(22.76%),P<0.05。维吾尔族OLP组HLAⅡ-DRB1*14等位基因表现频率(50.00%)显著高于正常对照组(9.52%),P<0.05。结论:HLAⅡ-DRB1*11等位基因可能与新疆地区汉族人群OLP患者易感性相关;HLAⅡ-DRB1*12等位基因可能是新疆汉族OLP患者的保护基因;HLAⅡ-DRB1*14等位基因可能与新疆地区维吾尔族OLP患者易感性有关。PURPOSE： To investigate the association of human leukocytes antigen HLA Ⅱ-DRB1 alleles between Han Chinese and Uygur people with oral lichen planus （OLP） in Xinjiang Uygur Autonomous Region. METHODS： The allele frequency of HLA Ⅱ -DRB1 was detected in 34 OLP patients vs 123 normal controls of Han Chinese group and 14 OLP patients vs 42 normal controls of Uygur people group by polymerase chain reaction-sequence specific primers （PCR-SSP） method. The data was analyzed with SPSS16.0 software package for Chi-square test and Fisher＇s exact test. RESULTS： The allele frequency of HLA Ⅱ -DRB1＊11 was significantly higher （23.53% vs 9.76% ）, however, HLA Ⅱ -DRB1＊12 was substantially lower （5.88% vs 22.76%） in OLP patients than that in normal controls in Han Chinese group, P〈0.05.The allele frequency of HIA Ⅱ-DRB1＊140 was significantly higher （50.00% vs 9.52% ） than that in normal controls in Uygur people group, P〈0.05. CONCLUSIONS： HLA Ⅱ -DRB1＊11 alleles could be the susceptible genes for OLP in Han Chinese in Xinjiang Uygur Autonomous Region, however, HLA Ⅱ-DRB1＊ 12 alleles might be the protective gene for OLP in Han Chinese in Xinjiang Uygur Autonomous Region. HLA Ⅱ -DRB1＊14 could be the susceptible genes for OLP in Uygur people in Xinjiang Uygur Autonomous Region.

关 键 词：口腔扁平苔藓 人类白细胞抗原 等位基因 汉族 维吾尔族 

分 类 号：R781.5[医药卫生—口腔医学]