细胞因子受体在抑郁模型大鼠电休克治疗中的表达  

Effessian of cytokine receptor in depressive rats treated electroshock therapy

作　　者：高新学[1] 况利[1] 李大奇[1] 艾明[1] 

机构地区：[1]重庆医科大学附属第一医院心理卫生中心,重庆400016

出　　处：《重庆医科大学学报》2008年第11期1317-1320,共4页Journal of Chongqing Medical University

基　　金：重庆市科委资助项目(渝科发计字[2004]54号)

摘　　要：目的:观察细胞因子受体对抑郁模型大鼠海马神经元及胶质细胞再生中的作用。方法:采用慢性轻度不可预见性的应激建立大鼠抑郁模型,对模型大鼠行电休克(Electric convulsive therapy,ECT)及丙泊酚无抽搐电休克(Modified electricconvulsive therapy,MECT)疗法,旷场分析进行行为学观察,免疫荧光方法观察神经元和胶质细胞上细胞因子受体的表达情况。结果:应激+ECT组、应激+MECT组与应激+假电击组比较,旷场分析、免疫荧光实验均有显著差异。结论:MECT治疗和ECT治疗能促进抑郁模型大鼠海马神经元及胶质细胞上细胞因子受体表达的改变,细胞因子可能参与抑郁症的病理机制,MECT治疗疗效可能较ECT治疗为优。Objective：To observe the expression of cytokine receptor in neuron and astrocyte of the hippocampus of rats in depression. Methods：The depression model was produced by separation and un-predicted mild stressors. The behavior was measured by open-field test.The rats acceived electric convulsive therapy（ECT） or modified electric convulsive therapy （MECT） treatment. The expression of cytokine receptor in neuron and astrocyte of the hippocampus was observed by the immunofluorescence detection technique. Results：There were significant differences among the stress and ECT group ,the stress and MECT group and the stress and shame-electroshock group in the two test. Conclusion：Both the ECT and the MECT treatment can promote the expression of cytokine receptor in neuron and astrocyte of the hippocampus of rats in depression. The cytokine（CK）may play an important role in the pathophysiological mechanism of depression. And the MECT treatment may be more effective than the ECT treatment.

关 键 词：抑郁症 海马 电休克 细胞因子受体 

分 类 号：R749[医药卫生—神经病学与精神病学]