香椿总黄酮降血糖作用的实验研究  

Experimental Studies on Hypoglycemic Effects of Total Flavonoid from Toona sinensis

作　　者：张俊芳[1] 杨加域[1] 温劲[1] 王定勇[2] 杨敏[1] 刘秋琼[1] 

机构地区：[1]广东省人民医院药学部,广东广州510080 [2]广东药学院药科学院,广东广州510006

出　　处：《中药材》2008年第11期1712-1714,共3页Journal of Chinese Medicinal Materials

基　　金：广东省社会发展领域科技计划立项资助(63056)

摘　　要：目的:研究香椿总黄酮(TSTF)对糖尿病小鼠动物模型的降血糖作用。方法:将四氧嘧啶用NS配成0.02 g/ml,按200 mg/kg注射到小鼠腹腔;连续2 d用葡萄糖灌胃(2 g/kg),早晚各一次,以葡萄糖氧化酶法测空腹血糖,大于11.00 mmol/L为造模成功小鼠。将入选小鼠随机分为模型组、TSTF低、高剂量组(0.06、0.12 g/kg)、降糖灵组(0.10 g/kg),另取20只正常小鼠为对照组(蒸馏水),灌胃1次/d,连续15 d,第16 d用葡萄糖氧化酶法测空腹血糖。结果:TSTF组四氧嘧啶小鼠血糖显著降低。结论:TSTF对四氧嘧啶所致糖尿病模型小鼠有降血糖作用。Objective： To study hypoglcemic effects of total flavonoid from Toona sinensis （TSTF） on diabetic mice model. Methods ： To confect alloxan 0. 02 g/ml with NS and injected alloxan into abdominal cavity to induce diabetic model, and all rats were fed bid with glucose for 2 consecutive days, then the blood glucose was detected by glucose oxidizes, when hypoglycemic point 〉 11.00 mmol/L the rats were successful model made. 100 model rats were divided into 5 groups as contrast groups （distilled water）, model control control groups, hight doses group（0. 12 g/kg）and low doses group（0. 6 g/kg） of TSTF, positive control groups of phenformin （0. 10 g/kg） ; In addition to set 20 natural rats（ distilled water）, and all groups were fed qd for 15 consecutive days, and then the blood glucose were detected by glucose oxidizes in the sixteenth day. Results：The blood glucose levels of the diabetic rats in TSTF groups significantly decreased. Conclusion ： TSTF can significantly decrease the blood glucose levels of diabetic mice induced by alloxan.

关 键 词：香椿 总黄酮 降血糖 糖尿病模型小鼠 

分 类 号：R285.5[医药卫生—中药学]