One-pot synthesis of 1,3,4-oxadiazole-5-thioethers in water  

水相一锅煮合成1，3，4-噁二唑-5-硫醚类化合物(英文)

作　　者：闫旭[1,2] 葛泽梅[1,2] 程铁明[1,2] 李润涛[1,2] 

机构地区：[1]北京大学 天然药物及仿生药物国家重点实验室 [2]药学院 化学生物学系,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》2008年第4期277-280,共4页中国药学（英文版）

基　　金：Natural Science Foundation of China (Grant No.20672009);the Major State Basic Research Development Program(Grant No.2004CB719900).

摘　　要：An efficient and environmental-friendly one-pot procedure has been developed for the synthesis of 1,3,4-oxadiazole-5- thioethers by the reaction of acylhydrazine with carbon disulfide and organic halides or α, β-unsaturated carbonyl compounds. The reactions were carried out in water in the presence of potassium phosphate within 2-4 h to afford the expected products in excellent yields.此文报道了由酰肼,二硫化碳及卤代烃或α,β-不饱羰基化合物在水相中一锅煮反应合成1,3,4-噁二唑-5-硫醚类化合物的方法。该方法具有高效、反应条件温和、操作简单、适用范围广和环境友好等优点。

关 键 词：1 3 4-Oxadiazole-5-thioether One-pot synthesis Environmental-friendly Aqueous medium Acylhydrazine Potassium phosphate 

分 类 号：R914[医药卫生—药物化学]