EGFR和Cyclin D1的联合表达预测胶质瘤的放疗敏感性  

The combined expression of EGFR and Cyclin D1 in predicting the radiosensitivity of glioma

作　　者：崔刚[1] 张熙[2] 周乐[1] 屈建强[1] 刘鹏斌[3] 

机构地区：[1]西安交通大学医学院第二附属医院神经外科,陕西西安710004 [2]西安交通大学医学院第一附属医院神经外科,陕西西安710061 [3]西安交通大学医学院第二附属医院麻醉科,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2008年第6期689-691,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省科技计划基金资助项目[No.2006K09-G2(12)]

摘　　要：目的探讨表皮生长因子受体(EGFR)和Cyclin D1蛋白的表达与胶质瘤放疗敏感性的关系。方法采用免疫组织化学方法检测EGFR和Cyclin D1蛋白在53例不同放疗敏感性胶质瘤和10例正常脑组织中的表达。结果EGFR或Cyclin D1蛋白的表达与胶质瘤的放疗敏感性均无统计学意义(P>0.05)。EGFR和Cyclin D1蛋白的联合表达与胶质瘤的放疗敏感性具有统计学意义(P<0.05)。结论EGFR和Cyclin D1蛋白的联合表达可预测胶质瘤的放疗敏感性。Objective To investigate the relationship between the expression of epidermal growth factor receptor （EGFR） and Cyclin D1 protein and the radiosensitivity of human glioma. Methods The expression of EGFR and Cyclin D1 was detected by SP immunohistochemical technique in brain glioma （n = 55） and normal brain tissues （n = 10）. Results There was no relationship between the expression of EGFR protein and the radiosensitivity of human glioma, so was the Cyclin D1 protein. But the expression of EGFR and Cyclin D1 protein was correlated with the radiosensitivity of human glioma. Conclusion The expression of EGFR and Cyclin D1 might serve as an indicator of radiosensitivity in human glioma.

关 键 词：EGFR蛋白 CYCLIN D1蛋白 脑胶质瘤 放疗敏感性 

分 类 号：R739.41[医药卫生—肿瘤]