吲哚美辛对舰员龈沟液中前列腺素和天冬氨酸转氨酶的作用  

EFFECT OF INDOMETHACIN ON ASPARTATE AMINOTRANSFERASE AND PROSTAGLANDINS IN GINGIVAL CREVICULAR FLUID IN MARINES

作　　者：陈铁楼[1] 刘景昌[2] 蔺世龙[2] 刘国勤[1] 许兵[3] 许恒[1] 张新海[1] 陈骏[1] 赵海军[1] 

机构地区：[1]解放军第四一一医院口腔中心,上海200081 [2]海军医学研究所 [3]同济大学化学系

出　　处：《解放军预防医学杂志》2008年第6期415-419,共5页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：全军重点实验室基金项目课题(No..036);国家自然科学基金项目课题(No.3870831);海军后勤部重点项目课题(No.2000-3327)

摘　　要：目的探讨吲哚美辛对舰员和地勤人员牙周炎龈沟液(GCF)中前列腺素(PGS)和天冬氨酸转氨酶(AST)的作用,为今后用PGS抑制剂治疗牙周炎提供依据。方法60例舰员和40例地勤牙周炎患者各分为4组:对照组、洁治组、吲哚美辛组、吲哚美辛结合洁治组,比较各组治疗前和治疗后1个月时牙周炎各临床参数及GCF中AST(GCF-AST)和前列腺素E 2(PGE 2)变化。结果舰员和地勤人员洁治组、吲哚美辛组、吲哚美辛结合洁治组在治疗1个月时牙周各临床指数均低于对照组差异均有显著性(P<0.01),且吲哚美辛结合洁治组的最低;治疗后舰员吲哚美辛结合洁治组GCF-AST为(389.4±42.4)U/L,GCF-PGE 2为(7.2±1.1)μg/L,明显低于吲哚美辛组〔GCF-AST(1 131.1±55.9)U/L,GCF-PGE 2(18.4±4.5)μg/L,P<0.01〕和洁治组〔GCF-AST(1 793.25±145.2)U/L,GCF-PGE 2(39.6±11.5)μg/L,P<0.01〕;地勤人员吲哚美辛合用洁治组GCF-AST(989.4±70.5)U/L,GCF-PGE 2(41.4±5.5)μg/L,明显低于吲哚美辛组〔GCF-AST(1 654.1±34.1)U/L,GCF-PGE 2(50.1±3.7)μg/L,P<0.01〕和洁治组〔GCF-AST(1 923.7±76.6)U/L,GCF-PGE 2(63.5±4.6)μg/L,P<0.01〕。舰员GCF-AST和GCF-PGE 2明显高于地勤人员,吲哚美辛合用洁治对舰员牙周临床指数及GCF-AST和GCF-PGE 2的作用强于地勤人员。结论吲哚美辛合用洁治对舰员牙周炎有明显的治疗作用,且对舰员的作用强于地勤人员。其机制可能与AST和PGE 2的变化有关。Objective To study the effects and mechanism of indomethacin on aspartate aminotransferase and prostaglandins in gingival erevieular fluid （GCF） in marines. Methods Sixty marines and 40 ground personnels with periodontitis were divided into 4 groups respectively： control group, sealing group, Indomethaein group, and scaling ＋ Indomethaein group. The gingival index （GI）, plaque index （PLI）, probing depth （PD）, attachment loss （AL）, tooth odontoseisis （TO） and the level of aspartate aminotransferase （AST） and prostaglandin E 2（PGE 2）in GCF of the 4 groups were measured. Results Significant differences in clinical indexes： GI, PD, AL, PLI, and TO in marines and ground personnels were seen in indomethacin, indomethaein ＋ scaling, and scaling groups when compared to control group （ P 〈 0.01） after 1 month of treatment, and the levels of those in indomethacin ＋ scaling group were the lowest. For marines, the levels of GCF-AST and GCF-PGE 2 [（389.4 ± 42.4）U/L, （7.2 ± 1.1）μg/L respectively] in indomethaein ＋ scaling group were lower than those in indomethacin group [（1 131.1± 55.9）U/L, （18.4 ± 4.5）μg/L respetively, P 〈 0.01], scaling group [ （ 1793.7± 145.2） U/L, （ 39.6 ± 11.5） μg/L respectively, P 〈 0. 01 ] after I month of treatment. For ground personnels, the levels of GCF-AST and GCF-PGE 2 in indomethaein ＋ scaling group [（989.4 ± 70.5）U/L, （41.4 ± 5.5）μg/L respectively] were also lower than those in indomethaein group [（ 1 654.1± 34.1 ） U/L, （50.1 ± 3.7）μL respectively, P 〈 0.011, and in scaling group [ （ 1 923.7 ± 76.6） U/L, （63.5 ± 4.6）μg/L respectively, P 〈 0.01]. The level of GCF-AST and GCF-PGE 2 after Indomethacin ＋ scaling therapy decreased more in marines than in ground personnels. Conclusion lndomethacin combined with periodontal scaling is beneficial to the marines with periodontitis, and the effects on marines are better than on ground personnels. The mechanism may be related to

关 键 词：吲哚美辛 舰员 龈沟液 天冬氨酸转氨酶 前列腺素类 

分 类 号：R781.4[医药卫生—口腔医学]