橄榄油的降脂作用及其作用机制研究  

Lipid-decreasing Effect of Olive Oil and Its Mechanism

作　　者：孔令斌[1] 张福国[2] 沙连生[3] 

机构地区：[1]济宁医学院 [2]济宁口腔医院 [3]日照市人民医院

出　　处：《济宁医学院学报》2008年第4期286-288,共3页Journal of Jining Medical University

基　　金：济宁市科技局课题(2004JH019)

摘　　要：目的探讨橄榄油的降血脂作用及其作用机制。方法将大鼠随机分为基础饲料喂养组、高脂饲料喂养组和高脂饲料加橄榄油组,喂养8周后分别测定其血清中TG、TC、LDL-C、apoA1、apoB、MDA含量、AI及肝脏组织中的TG、TC含量。结果大鼠血清TG、TC、LDL-C、apoA1、apoB、MDA、AI和肝脏组织中TC、TG含量水平均呈现出高脂饲料喂养组>高脂饲料加橄榄油喂养组>基础饲料喂养组(P<0.05)。结论橄榄油能通过调节大鼠的LDL-C、apoA1、apoB、MDA含量和AI降低大鼠的血脂水平。Objective To explore lipid - decreasing effect of olive oil and its mechanism. Methods The rats were randomly divided into three groups：basal fed group, hyper fat fed group and hyper fat plus olive oil group. All the groups were fed for 8 weeks and the serum total cholesterol （ TC ）, triglyceride （ TG）, low - density lipoprotein cholesterol （LDL- C）,apoA1 ,apoB,malonaldehyde （MDA） levels and the liver tissue TG,TC levels were measured in each group. Results The serum TG, TC, LDL - C, apoA1, apoB, MDA levels and AI of three groups were showed a significant difference ： hyper fat fed group 〉 hyper fat plus olive oil group 〉 basal fed group （ P 〈 0.05 ） ; the liver tissue TG,TC levels of three groups were also showed a significant difference ： hyper fat fed group 〉 hyper fat plus olive oil group 〉 basal fed group （ P 〈 0.05 ）. Conclusion Oliver oil has a marked antihyperlipidemic effect on hyperlipidmia model rats, and it could prevent and treat cardiovascular and cerebrovascular disease.

关 键 词：橄榄油 大鼠 脂质 

分 类 号：R151.3[医药卫生—营养与食品卫生学] R972.6[医药卫生—公共卫生与预防医学]