配比多级暴露水平分析黄曲霉毒素加合物与肝癌关系的病例对照研究  

The Relation of Aflatoxinalbumin Adducts to PLC Using and Analytical Method for Multiple Level Data of Matching Casecontrol Study

作　　者：董传辉[1] 俞顺章[1] 陈公超[1] 

机构地区：[1]上海医科大学流行病学教研室 [2]江苏省海门市卫生防疫站

出　　处：《中国公共卫生学报》1998年第1期19-21,共3页

基　　金：国家自然科学基金

摘　　要：采用配比多暴露水平分析方法，对６４对（１∶１）血清白蛋白黄曲霉毒素加合物水平与肝癌关系的病例对照研究资料进行分析。结果表明：黄曲霉毒素加合物水平与肝癌危险有关（ｘ２全局＝１７．０３４８，ｄｆ＝３，Ｐ＜０．０１；同＜７．０（ｐｇ／ｍｇＨＳＡ）相比较，７．０～１２．５、１２．６～２３．０和＞２３．０（ｐｇ／ｍｇＨＳＡ）３个水平的估计危险优势比分别为３．９８、６．８３和１３．９７，趋势检验有显著性统计学意义（ｘ２趋势＝１６．２４３６，ｄｆ＝１，Ｐ＜０．００１）。An analytioal method for multiple exposure level data of mathing(1∶1) casecontrol study was employed in the study on the relatioship between aflatoxinalbumin adducts(AFTHSA) and primary liver cancerPLC).The result showed that there was a signifioant assooiation of PLC with AFTHSA(x 2=17 0384,df=3,P<0 01.Compared with the adduct level of <7 0(pg/mg HSA),the odds ratios(OR s) for levels of 7 0-12 5,12 623 0(pg/mg HSA)were 3 98,6 83 and 13 97,respectively;and there was an obvious dosereaction linkage among the levels of AFTHSA and OR s(x 2 trend =16 2436,P<0 001).

关 键 词：肝癌 黄曲霉毒素 对照研究 

分 类 号：R735.7[医药卫生—肿瘤]