TMS1/ASC基因甲基化与肿瘤的相关性  

The relationship between the methylation of ASC/TMS1 gene and tumor

作　　者：张剑[1] 左云飞[1] 

机构地区：[1]大连医科大学检验医学院,大连116044

出　　处：《生命的化学》2008年第6期740-743,共4页Chemistry of Life

基　　金：国家自然科学基金(30870550)资助

摘　　要：细胞凋亡相关的斑点样蛋白(ASC)由PYRIN(PYD)和CARD组成,是可逆的衔接分子。DNA甲基化是一种可遗传性修饰,它有利于调节基因组的完整性并保证适当的基因表达。ASC在某些肿瘤中被甲基化而沉默,并表现生长抑制活性。本文对TMS1/ASC甲基化后表达沉默与癌之间的关系做一综述。Apoptosis-associated specklike protein （ASC）, which is composed of PYRIN （PYD） and CARD, is an reversible adapter molecule. Methylation of DNA is an inheritable modification that is responsible for maintaining the integrity of the genome and guarantee the adequate genetic expression. ASC is methylated and silent in some tumor, and shows growth inhibitory activity. This review discusses the relationship between that methylation of ASC/TMS1 and silence and tumor.

关 键 词：TMS1/ASC基因 CARD PYRIN TMS1/ASC甲基化 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]