小鼠缺氧预处理对不同因素缺氧耐受性的影响  

Influence of hypoxic precondition to different factors'anxic tolerance

作　　者：林娜[1] 周风铃[1] 王建礼[2] 孙梦语[1] 

机构地区：[1]山东省济宁医学院基础学院机能实验室,272013 [2]济宁医学院病理生理学教研室

出　　处：《中国实用医药》2009年第2期46-47,共2页China Practical Medicine

摘　　要：目的研究缺氧预处理对不同因素缺氧耐受性的影响。方法于室温下复制小鼠的急性重复缺氧模型,给予筒箭毒碱、咖啡因药物,来观察记录小鼠的一般状态及存活时间。结果急性缺氧预处理后,小鼠对筒箭毒碱、咖啡因的缺氧耐受性与对照组相比,P<0.05,差异具有统计学意义;腹腔注射筒箭毒碱与注射生理盐水相比,差异具有统计学意义。结论急性缺氧预处理可以提高小鼠对缺氧的耐受性。Objective The Influence of hypoxic precondition to different factors＇ anxic tolerance was studied in acute hypoxia pretreated mice. Methods Duplicates mouse＇ s acute hypoxic precondition model under the room temperature, recording mouse survival time. Results Dynamic changes were monitored by intraperitoneal injection. Conclusion Hypoxic precondition and tubocurarine can enhance anxic tolerance of mice, and both of them can be used at the same time.

关 键 词：缺氧 急性缺氧预处理 筒箭毒碱 咖啡因 

分 类 号：R363[医药卫生—病理学]