4-[(E)-2-(3，4，5-三甲氧基苯基)乙烯基]苯氧基羧酸酯的合成及抗肿瘤活性研究  

Synthesis and anti-tumor activities of 4-[(E)-2-(3,4,5-trimethoxyphenyl) vinyl] phenoxy carboxylic ester

作　　者：杜娟[1] 张喜全[2] 郭键[1] 顾红梅[2] 徐宏江[2] 李宝林[1] 

机构地区：[1]教育部药用植物资源与天然药物化学重点实验室、陕西师范大学化学与材料科学学院,陕西西安710062 [2]江苏正大天晴药业股份有限公司,江苏南京210038

出　　处：《化学研究与应用》2009年第1期120-122,共3页Chemical Research and Application

基　　金：教育部重点科学研究项目(105153)

摘　　要：Two new resveratrol analougues,t-butyl 4-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]phenoxy i-butyrate and ethyl 4-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]phenoxy n-butyrate,are synthesized from 3,4,5-trimethoxybenzaldehyde and p-nitrotoluene via mutil-steps including condensation,catalytic reduction,diazotization,hydrolyzation,nucleophilic substitution.The effect of the new compounds on HL-60 and A549 cell proliferation are tested by MTT.The results show that the two new compounds exhibite the activities of anti-tumor proliferation.Two new resveratrol analougues, t-butyl 4- [ （ E ） -2- （ 3,4,5 -trimethoxyphenyl ） vinyl ] phenoxy i-butyrate and ethyl 4- [ （ E）-2-（ 3,4,5-trimethoxyphenyl ） vinyl ] phenoxy n-butyrate, are synthesized from 3, 4, 5-trimethoxybenzaldehyde and p- nitrotoluene via mufti-steps including condensation, catalytic reduction, diazotization, hydrolyzation, nucleophilic substitution. The effect of the new compounds on HL-60 and A549 cell proliferation are tested by .MTT. The results show that the two new compounds exhibite the activities of anti-tumor proliferation.

关 键 词：白藜芦醇类似物 二苯乙烯衍生物 抗肿瘤活性 合成 

分 类 号：O626[理学—有机化学]