海门地区黄曲霉毒素暴露与肝癌危险流行病学研究  

An epidemiological study on the association of exposure to aflatoxin with primary liver cancer

作　　者：董传辉[1,2,3] 俞顺章[1,2,3] 陈公超[1,2,3] 赵德明[1,2,3] 符艳[1,2,3] 

机构地区：[1]上海医科大学流行病学教研室 [2]江苏省海门市卫生防疫站 [3]上海医科大学预防医学系

出　　处：《实用肿瘤杂志》1998年第3期140-142,共3页Journal of Practical Oncology

基　　金：国家自然科学基金;国家教委博士点基金

摘　　要：对１９９６年在江苏海门进行的以人群为基础的肝癌病例与对照研究对象血清各６４份，并从海门肝癌队列研究对象中采集１９８７年、１９９２年一般人群的血清６２份和７４份。应用夹心ＥＬＩＳＡ法测定黄曲霉毒素血清清蛋白加合物水平。结果表明：ＡＦＴ－ＨＳＡ水平与肝癌危险明显相关（ＯＲ＝２．４０，９５％ＣＩ１．５０～３．８３，Ｐ＜０．０００１），且肝癌危险度随加合物水平升高而明显增高（χ２＝１５．１４２，Ｐ＝０．０００１）。比较１９８７年、１９９２年和１９９６年当地居民加合物水平发现，１９９２年和１９９６年加合物水平较１９８７年有明显下降。说明改食大米为主粮虽使得当地居民摄入黄曲霉毒素量有所下降。AFT HSA adducts were measured by sandwich ELISA in sera from 64 patients with PLC and 64 controls recruited in a case control study, conducted in Haimen, Jiangsu in 1996, and from 62 residents and 74 residents collected in 1987 and 1992, respectively. It was found that the association of AFT HSA with risk of PLC was of significance (OR=2.40, 95%CI 1.50～3.63, P <0.0001),and there was an obvious dose effect relationship between the level of adducts and odds ratio(OR) ( χ 2=15.142, P =0.0001). Compared with those in 1987, the levels of adducts in residents in 1992 and in 1996 were decreased significantly. It suggested that exposure to aflatoxin may still be one of risk factors leading PLC in Haimen population.

关 键 词：黄曲霉毒素 危险度 原发性 肝肿瘤 

分 类 号：R735.7[医药卫生—肿瘤] R379.6[医药卫生—临床医学]