MPO与TGF-β1在溃疡性结肠炎中的表达  

Expression of MPO and TGF-β1 in Ulcerative colitis

作　　者：王燕颖[1] 孙丽芳[1] 禹晶[1] 王燕锋[1] 杨志伟[1] 毛晓光[1] 张沛怡[1] 王寅东[1] 

机构地区：[1]黑龙江省医院消化内科,黑龙江哈尔滨150036

出　　处：《中国医师杂志》2009年第1期31-33,共3页Journal of Chinese Physician

基　　金：黑龙江省人事厅归国留学人员科技资助项目（2005163）

摘　　要：目的探讨髓过氧化物酶（MPO）和转化生长因子β1（TGF—β1）在溃疡性结肠炎中的表达及意义。方法通过免疫组织化学染色法（两步法）检测37例溃疡性结肠炎，10例克罗恩肠病及20例正常结肠组织中MPO和TGF-β1的表达。结果MPO和TGF—β1阳性表达在溃疡性结肠炎组织中（89．2％，86．5％）均显著高于克罗恩肠病（55．0％，35．0％）和正常结肠组织（10．0％，20．0％），差异均有统计学意义（P〈0．05）。MPO和TGF—β1在溃疡性结肠炎组织中的表达有相关性（r=0．51，P〈0．05）。结论MPO和TGF—β1参与溃疡性结肠炎的发病，检测MPO和TGF-β1对研究溃疡性结肠炎的发病机制和判断溃疡性结肠炎的病情具有一定的参考价值。Objective To explore the expression and effect of MPO and TGF-β1 in ulcerative colitis tissues. Methods The expressions of MPO and TGF-β1 in colonal tissue specimens were determined by immunohistochemistry（ two step method） in 37 cases of ulcerative colitis, 10 crohn＇s disease and 20 normal mucosa. Results The positive rates of MPO and TGF-β1 were 10% and 20.0% in the normal mucosa, 55.0 % and 35.0 % in crohn＇s disease, and 89. 2 % and 86. 5 % in ulcerative colitis. Expression of MPO and TGF-β1 in the ulcerative colitis were higher than that in crohng disease and normal mucosa （ P 〈0. 05）, there was correlation between MPO and TGF-β1 （ r = 0. 51, P 〈 0.05 ）. Conclusion MPO and TGF-β1 are involved in the pathology of UC , and detection of MPO and TGFβ1 can provide some value to evaluate the conditions of UC.

关 键 词：过氧化物酶 转化生长因子Β 结肠炎 溃疡性 

分 类 号：R57[医药卫生—消化系统]