乙醛脱氢酶1在结肠癌组织中的表达及意义  

Expression of ALDH1 and its significance in colon cancer

作　　者：潘兆军[1] 江志敏[1] 郭运杰[1] 姚和瑞[1] 

机构地区：[1]中山大学附属第二医院肿瘤科,广州510120

出　　处：《中华普通外科学文献（电子版）》2009年第1期16-17,26,共3页Chinese Archives of General Surgery(Electronic Edition)

基　　金：广东省医学科研基金资助课题(A2005226);广东省自然科学基金资助课题(7001592);广东省科技计划资助课题(2006B36002010)

摘　　要：目的探讨乙醛脱氢酶1（Mdehyde—dehydrogenase Class 1，ALDH1）在结肠癌组织中的表达情况及临床意义。方法应用免疫组织化学SP法对76例术前未行放、化疗的结肠癌标本及正常结肠黏膜组织进行ALDH1检测，并结合肿瘤临床病理特征、预后进行分析。结果根据Q评分（quickscore），肿瘤组织ALDH1的表达范围由0～240不等，按Q〉120为高表达的标准，高表达率为34．2％（26／76）。正常结肠组织不表达或低表达ALDH1。ALDH1的表达与结肠癌患者年龄、性别、血型、血CEA水平、淋巴结转移、分化程度、浸润深度、Duke’s分期均无明显相关。ALDH1高表达组结肠癌患者的5年生存率明显低于低表达组（30％比69％，P=0．040）。结论ALDH1在结肠癌组织中有一定高表达率，其高表达提示预后不良，可作为评价结肠癌预后指标。Objective To evaluate the expression of aldehyde-dehydrogenase class 1 （ALDH1） in colon cancer and its significance. Methods Expression of ALDH1 protein was investigated by immunohistochemical staining method in 76 cases colon cancer tissues without the history of radiotherapy or chemotherapy and normal colonic mucosal tissue. Results ALDH1 was detected in 34.2%（26/76） colon cancer tissues. There was no relationship between ALDH1 protein expression and age, gender, blood group, serum CEA level, lymph-node metastasis, histological grade, infiltration degreed and Dukes stage. When Q〉120 was used as the eut-offpoint of high and low expression of ALDH1, the 5-year overall survival rate of low expression group was much higher than the high expression group （ 69% rs 30%, P =0.040 ）. Conclusions Expression of ALDH1 can be detected in colon cancer. The higher level ofALDH 1 is related with poor prognosis and it may be a potential prognostic index.

关 键 词：结肠肿瘤 醛脱氢酶 ALDH1 预后 

分 类 号：R735.35[医药卫生—肿瘤] R575[医药卫生—临床医学]