AKT/mTOR信号通路在喉癌组织中的表达及意义  

Expression and Significance of AKT/mTOR Signal Pathway in Laryngeal Cancer

作　　者：贾涛[1] 雷文斌[2] 苏振忠[2] 祝小林[2] 文卫平[2] 廖冰[3] 

机构地区：[1]山东大学第二医院耳鼻咽喉科,山东济南250033 [2]中山大学附属第一医院耳鼻咽喉科医院 [3]中山大学附属第一医院病理科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2009年第1期35-38,42,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省自然科学基金博士科研启动基金(5300781);广东省科技计划项目(60501022)

摘　　要：【目的】研究AKT/mTOR信号通路在喉鳞状细胞癌组织中的表达及其与临床病理因素之间的关系。【方法】用免疫组化染色测定p-AKT和p-mTOR在喉癌(84例)、癌旁(24例)和正常黏膜组织(20例)中的表达情况,分析其与常见临床病理因素之间的关系。【结果】p-AKT在喉癌、癌旁和正常黏膜组织中的阳性表达分别为78.3%、29.2%、25%,p-mTOR在喉癌、癌旁和正常黏膜组织中的阳性表达分别为76.4%、50%、20%;AKT/mTOR信号通路的过度表达在喉癌、癌旁和正常黏膜组织中的表达呈递减的趋势;喉鳞状细胞癌组织中p-Akt与p-mTOR蛋白的表达呈正相关;此通路在喉癌组织中的表达与病理分化程度呈负相关性。【结论】AKT/mTOR信号通路在大部分喉癌组织中过度表达,可能是喉癌发生发展的重要机制之一。[Objective] This study aimed to explore the expression of AKT/mTOR （Protein kinase B/mammalian target of rapamycin） signal pathway in laryngeal squamous cell cancer and the relationship between the expression with the clinical and pathological factors in laryngeal cancer. [Method] The expression of p-AKT and p-mTOR in laryngeal cancer （84 cases）, paracancer （24 cases） and normal mucosa tissues （20 cases） were measured by immunohistochemical test, and then their relationship with clinical and pathological factors were analyzed. [Result] The expression of p-AKT in laryngeal cancer, paracancer and normal mucosa tissues were 78.3%, 29.2%, and 25%, respectively. And the expression of p-mTOR were 76.4%, 50%, and 20%, respectively. The expression of AKT/mTOR signal pathway decreased gradually in these specimens. The expression of p-AKT and p-mTOR in laryngeal cancer were positively relative. Furthermore, the expression of this signal pathway was negatively associated with the pathological differentiation degree. [Conclusion] AKT/mTOR signal pathway over expressed in most of laryngeal cancer. It may play an important role in occurrence and development of laryngeal cancer.

关 键 词：AKT MTOR 喉癌 病理分化 

分 类 号：R73[医药卫生—肿瘤]