食品添加剂KAl(SO_4)_2中Al的吸收、排泄、蓄积实验研究  

STUDY ON THE ABSORPTION,EXCRETION AND RETENTION OF ALUMINUM FROM FOOD ADDITIVE——KAL(SO4)2

作　　者：张万起[1] 徐格晟[1] 黄国伟[1] 任大林[1] 陈杰[1] 

机构地区：[1]天津医科大学营养与食品卫生学教研室

出　　处：《天津医科大学学报》1998年第1期1-5,共5页Journal of Tianjin Medical University

基　　金：卫生部科研基金

摘　　要：目的：探讨我国主要含铝食品添加剂——硫酸铝钾中铝的吸收、排泄和贮留的基本情况。方法：１．采用６月龄日本雄性大耳兔８只进行３天的代谢平衡实验。２．选用２～３月龄２１只雄性兔进行３２周的蓄积实验。结果：代谢实验表明铝的表观吸收率平均在１０％左右，约９０％的口服铝在粪中排出。尿铝随摄入铝的增加而增加，但肾排铝能力不足吸收的１０％。兔的蓄积实验证明在３２周实验后实验兔随铝摄入的增加其主要脏器均有不同程度的铝蓄积。其蓄积量的顺序为：骨＞肝＞肾＞脑＞心（３．８９～１０５．４６ｍｇ／ｋｇ干重）；蓄积增长倍数为：肝＞脑＞肾＞骨＞心（１．５１～４．５８倍）。结论：１．食品添加剂硫酸铝钾中铝的表观吸收率平均在１０％左右。尿铝随摄入铝的增加而增加，但肾排铝量不足吸收的１０％。２．长期大量摄入含铝食品添加剂可导致机体铝蓄积，其中脑、骨、肝、肾蓄积较明显。Objective:To study of the absorption,excretion and rtention of aluminum in potassium sulfate (alum)-a main food additive using in chinaMethods:The study was conducted in male white rabbits to by 3 days metabolism test and 32 weeks retention testResults:The metabolism test showed that the apparent absorption rate of Al was about 10% averagely,and about 90% of the oral dose of Al was excreted in fecesUrinary Al excretion was increased with the intake increaseBut such kidney excretory capacity was limited,only less than 10% of the absorbed Al was excreted in urineAfter 32 weeks treatment in the retention test,the retention of Al in the organs of rabbits was increased with Al intake increaseThe order of Al accumulation amount was:bone>liver>kidney>brain>heart (range of 389￣10546mg/kg dry wt);and the order of Al retention increasing times was:liver>brain>kidney>bone>heart(range of 151￣458)Conclusion:The apparent absorption rate of Al was about 10% averagelyUrinary Al excretion was increased with the intake increaseBut such kidney excretory capacity was limited,only less than 10% of the absorbed Al was excreted in urine,so these would result in the accumlation of Al in body

关 键 词：食品添加剂 铝 吸收 排泄 蓄积 

分 类 号：TS202[轻工技术与工程—食品科学] R155.33[轻工技术与工程—食品科学与工程]