药物设计与同步辐射  

Drug design and synchrotron

作　　者：张海涛[1] 沈旭[1] 

机构地区：[1]中国科学院上海药物研究所,上海201203

出　　处：《生命科学》2009年第1期7-10,共4页Chinese Bulletin of Life Sciences

摘　　要：当代药物设计是通过阐明药物与靶标相互作用的机理,对药物先导化合物进行改造和优化。利用晶体X射线衍射的方法获得药物与靶标复合物的结构,为药物设计提供最直接有力的依据。同步辐射凭借其高强度、低发散性、波长可调谐性等得天独厚的优势,实现了对药物与靶标复合物结构的高通量测定,大大提高了基于结构的药物设计效率。Drug design is based on the mechanisms of the drug and target interaction to achieve optimization of the leads. The structures of drug-target complexes obtained by X-ray crystallography provide direct and convictive evidences for drug design. Synchrotron has the advantages of high intensity, low divergence and tunability, so that it can be used for high-throughput data collection of complex structures, thus improving the efficiency of structure-based drug design.

关 键 词：药物设计 晶体X射线衍射 同步辐射 

分 类 号：R914.2[医药卫生—药物化学] O571.436[医药卫生—药学]