火针层孔菌(桑黄)粗多糖对荷瘤小鼠的免疫调节研究  

Immunological regulation of Phellinus igniarius crude polysaccharides to tumor bearing mice

作　　者：宋爱荣[1] 王光远[1] 赵晨[1] 何忠诚[1] 左宗保[1] 

机构地区：[1]青岛农业大学应用真菌省级重点实验室,青岛266109

出　　处：《菌物学报》2009年第2期295-298,共4页Mycosystema

基　　金：山东省2007年科技攻关项目

摘　　要：研究了火针层孔菌不同粗多糖对荷瘤小鼠的免疫调节作用。荷瘤小鼠随机分为四组:胞外粗多糖组、菌丝体粗多糖组、子实体粗多糖组和生理盐水阴性对照组。给药10d后测定荷瘤小鼠脾NK细胞活性和脾淋巴细胞的增殖率。结果显示火针层孔菌粗多糖组与阴性对照组相比能够提高小鼠脾NK细胞活性和脾淋巴细胞的增殖率(P<0.01),表明火针层孔菌液体发酵粗多糖和子实体粗多糖对荷瘤小鼠免疫功能均有调节作用。This paper deals with different immunological regulation effects of Phellinus igniarius crude polysaccharides on tumor-beating mice. The tumor bearing mice were divided into four groups at random： crude exo-polysaccharide treatment group, mycelium crude polysaccharide treatment group, fruit body crude polysaccharide treatment group and negative group. The treated mice were killed in 10 days and the activity of natural killer cells （NK） and the lymphocyte proliferation were investigated. The results indicate that as compared with negative group, all of the tested groups could enhance the activity of NK cells and the lymphocyte proliferation （P〈0.01）, suggesting that both the fermented and the fruit body crude polysaccharides of Phellinus igniarius had regulatory effects on the immunity of tumor bearing mice.

关 键 词：胞外多糖 菌丝体多糖 子实体多糖 NK细胞活性 淋巴细胞增殖率 

分 类 号：R245[医药卫生—针灸推拿学]