Quantitative differences in protein expression between cisplatin sensitive COC1 ovarian carcinoma cells and cisplatin resistant COC1/DDP cells  

Quantitative differences in protein expression between cisplatin sensitive COC1 ovarian carcinoma cells and cisplatin resistant COC1/DDP cells

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作  者:WANG Hui-xiang SUN Wei LI He-lian ZHANG Wei-yuan 

机构地区:[1]Department of Obstetrics and Gynecology, Second Hospital,Tsinghua University, Beijing 100049, China [2]Department of General Surgery, Second Hospital, China MedicalUniversity, Shenyang, Liaoning 110001, China [3]Department of Obstetrics and Gynecology, Second Hospital, JilinUniversity, Changchun, Jilin 130041, China [4]Department of Obstetrics and Gynecology, Beijing Obstetrics andGynecology Hospital, Capital Medical University, Beijing 100026,China

出  处:《Chinese Medical Journal》2009年第7期865-869,共5页中华医学杂志(英文版)

摘  要:Ovarian cancer is the second most common cancer of the reproductive system in women and is the leading cause of death from gynecological cancers. Despite good response to surgery and initial chemotherapy, the resistance to platinum in some ovarian cancers represents a major obstacle to successful therapy. A number of mechanisms for ovarian cancer platinum resistance have been reported. These mechanisms include the reduction of cisplatin accumulation within cancer cells, the ability to detoxify cisplatin, faster repair of cisplatin-DNA adducts, modulation of apoptotic pathways, up-regulation of transcription factors, and a higher concentration of glutathione and metallothioneins.Ovarian cancer is the second most common cancer of the reproductive system in women and is the leading cause of death from gynecological cancers. Despite good response to surgery and initial chemotherapy, the resistance to platinum in some ovarian cancers represents a major obstacle to successful therapy. A number of mechanisms for ovarian cancer platinum resistance have been reported. These mechanisms include the reduction of cisplatin accumulation within cancer cells, the ability to detoxify cisplatin, faster repair of cisplatin-DNA adducts, modulation of apoptotic pathways, up-regulation of transcription factors, and a higher concentration of glutathione and metallothioneins.

关 键 词:CHEMORESISTANCE ovarian cancer proteomics molecular markers gel electrophoresis 

分 类 号:R737.31[医药卫生—肿瘤] R734.2[医药卫生—临床医学]

 

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