Diagnosis and Treatment of Clear Cell Hidradenocarcinoma of the Scalp  

作　　者：舒凯 肖群根 Fabian Büchele 张所军 蒋伟 雷霆 

机构地区：[1]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology [2]Lab of Molecular Neurosurgery, Stereotactic and Functional Neurosurgery of Albert-Ludwigs University

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2012年第6期931-936,共6页华中科技大学学报（医学英德文版）

基　　金：supported by grants from National Natural Science Foundation of China (No.81100946);Natural Science Foundation of Hubei Province (No. 2011CDB560);China Postdoctoral Science Foundation (No.CPSF 20090460948);Robert-Bosch Foundation (No.32.5.8003.0079.0)

摘　　要：Clear cell hidradenocarcinoma (CCH) is an exceedingly rare and highly malignant tumor of the eccrine sweat glands. Its treatment is extremely difficult due to the characteristically aggressive clinical course including repeated local recurrence and uncontrollable distal metastasis coming along with a very poor prognosis. Most published case studies recommend a wide surgical excision followed by adjuvant conservative therapy, which is generally considered to be the standard treatment. Two cases of nodular CCH of the scalp either presenting as a singular primary lesion or at an already metastatic stage were analyzed retrospectively. Wide local excision of the tumor couldn’t prevent the primary carcinoma from recurring and metastasizing. Both cases received various therapies but the results were unsatisfactory. Although most authors have recommended that early wide surgical excision of the tumor is a feasible therapeutic measurement, our results raise doubts on the efficacy of this treatment strategy. As alternative approaches (i.e. chemotherapy, radiotherapy) are similarly controversial, further studies and a wide exchange of clinical experiences are crucial.Clear cell hidradenocarcinoma (CCH) is an exceedingly rare and highly malignant tumor of the eccrine sweat glands. Its treatment is extremely difficult due to the characteristically aggressive clinical course including repeated local recurrence and uncontrollable distal metastasis coming along with a very poor prognosis. Most published case studies recommend a wide surgical excision followed by adjuvant conservative therapy, which is generally considered to be the standard treatment. Two cases of nodular CCH of the scalp either presenting as a singular primary lesion or at an already metastatic stage were analyzed retrospectively. Wide local excision of the tumor couldn’t prevent the primary carcinoma from recurring and metastasizing. Both cases received various therapies but the results were unsatisfactory. Although most authors have recommended that early wide surgical excision of the tumor is a feasible therapeutic measurement, our results raise doubts on the efficacy of this treatment strategy. As alternative approaches (i.e. chemotherapy, radiotherapy) are similarly controversial, further studies and a wide exchange of clinical experiences are crucial.

关 键 词：hidradenocarcinoma SCALP DIAGNOSIS TREATMENT 

分 类 号：R739.5[医药卫生—肿瘤]