油菜蜂花粉及其组分对迟发型超敏反应的影响  

Effects of BPBC and Its fractions against the Delayed-type Hypersensitivity in Mice

作　　者：孙丽萍[1] 侯晓明[2] 廖磊[2] 张智武[1] 

机构地区：[1]中国农业科学院蜜蜂研究所,北京100093 [2]北京市卫生局临床药学研究所,北京100000

出　　处：《蜜蜂杂志》2007年第S1期40-42,共3页Journal of Bee

摘　　要：为了探讨油菜蜂花粉及其组分对正常小鼠迟发型超敏反应(DTH)的影响,采用2、4-二硝基氯苯(DNCB)腹部皮下致敏、耳廓发敏的方法建立DTH小鼠动物模型,观察耳部肿胀、胸腺指数及脾指数。结果花粉及其各提取组分均能抑制DNCB诱导的小鼠DTH(P<0.05)。其中三氯甲烷提取组分和水提取组分有非常显著的抑制作用(P<0.01),但对胸腺、脾脏指数无明显影响。结果表明,油菜蜂花粉及其组分能抑制细胞免疫反应,具有显著的免疫活性。To observe the effects of BPBC and its fractions a- gainst the delayed-type hypersensitivity in mice.Methods :The de- layed-type hypersensitivity animal model in mice was established by injection of DNCB,and the auricle swelling,spleen index and thy- mus index in right mice were determined.Results :BPBC and its dif- ferent fractions benefited to reduce auricle swelling in mice with al- lergic reaction induced by DNFB at different degree.Conclusion: BPBC and its different fractions can inhibit the delayed allergic reac- tion in mice induced by DNCB and depress the ability of specific ceil-mediated immunity.

关 键 词：油菜蜂花粉 提取组分 迟发型超敏反应 免疫调节 

分 类 号：S896.4[农业科学—特种经济动物饲养] R392[农业科学—畜牧兽医]