Comparative FTIR spectroscopic analysis of human breast benign and malignant tissues  

作　　者：Yunxiang Ci Tiyu Gao Jun Feng Zhenquan Guo Xiu Kan Jiangqiang Dong 

机构地区：[1]Peking Univ, Dept Chem, Beijing 100871, Peoples R China [2]Peking Univ, Dept Biol, Beijing 100871, Peoples R China [3]Beijing Med Univ, Dept Pathol, Beijing 100044, Peoples R China

出　　处：《Chinese Science Bulletin》1999年第9期804-808,共5页

摘　　要：Some remarkable FTIR spectral differences are observed and the differences at the molecular level are extracted between benign and malignant breast tissue samples. For the malignant tissue, the relative content of nucleic acids is increased whereas the collagen is decreased. The proteins are phosphorylated and become more flexible and disordered. And these significant differences have important implications not only for probing the process of the breast lesion at the molecular level, but also for evaluating the histological types and grades of breast diseases.Some remarkable FTlR spectral differences are observed and the differences at the molecular level are extracted between benign and malignant breast tissue samples. For the malignant tissue, the relative content of nucleic acids is increased whereas the collagen is decreased. The proteins are phosphorylated and become more flexible and disordered. And these significant differences have important implications not only for probing the process of the breast lesion at the molecular level, but also for evaluating the histological types and grades of breast diseases.

关 键 词：infrared spectroscopy BREAST BENIGN and MALIGNANT tissues. 

分 类 号：R737.9[医药卫生—肿瘤]