Effective cellular vaccines generated by in vitro or in vivo modification of tumor cells using gene transfer approaches for cancer immunogene therapy  

作　　者：Y.J.Guo F.Shen T.P.Xie X.Che Z.F.Cui L.Shi J.Ma S.G.Wu X.N.Wang G.L.Liu Y.Liu H.Wang H.L.Huang L.X.Wei J.Zhao J.Trojan A.Ly D.Anthony M.C.Wu 

机构地区：[1]Tumor Immunology and Gene Therapy Center,Institute of Hepatobiliary Surgery and Changhai Hospital,The Second Military Medical University and Sidney Kimmel Cancer Center,California,USA

出　　处：《中国实验血液学杂志》1997年第3期284-285,共2页Journal of Experimental Hematology

摘　　要：Tumor cells escape host immune surveillance bydown-regulation of MHC and/or co-stimulatorymolecules.Anti-tumor immune responses are mediated primarily by T cells.A deficiency in either MHC or co-stimulatory molecules on tumor cells is associated with a failure to induce anti-tumor immunity.

关 键 词：vaccines surveillance immunity TRANSFECTION recurrence MANNER ESCAPE CURATIVE elicit inducing 

分 类 号：R730.3[医药卫生—肿瘤]