Retroviral mediated human β-globin gene transfer and expression in vitro  

作　　者：Depei Liu, Chih-Chuan Liang National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005 

出　　处：《中国实验血液学杂志》1997年第3期286-286,共1页Journal of Experimental Hematology

摘　　要：Retroviral mediated gene transfer of humanglobin gene into hematopoietic stem cells is apromising approach for thalassemia gene therapy.Major problem of the transferred globin gene was lowlevel expression of the gene with its proximal cis-acting sequence. The locus control region (LCR) ofthe human β-globin gene cluster consists of four majorDNase I hypersensitive sites (HS). When linked

关 键 词：GLOBIN HEMATOPOIETIC proximal HYPERSENSITIVE locus enhancer packaging Major transferred induction 

分 类 号：R346[医药卫生—基础医学]