I mmunomodulatory effects of murine melanoma cells transduced with interleukin-2 gene and recombinant interferon-γ  

作　　者：Wei-Ming Ouyang, Ning Mao, Jian-Min Sun, Chun-Mei Hou, Jing-Qing Yang, De-Lin Du Department of Cell Biology, Beijing Institute of Basic-Medical Sciences, Beijing 100850 

出　　处：《中国实验血液学杂志》1997年第3期312-313,共2页Journal of Experimental Hematology

摘　　要：The murine interleukin-2 gene was introduced intomurine melanoma B16 cells by retroviral vector. AfterG418 selection, a clone stably secreting high level ofinterleukin-2 (1038IU per 10~6 cells per 24 hours) wasobtained. The tumorigenicity of this clone decreasedsignificantly as compared with parental tumor cells andtumor cells transferred neomycin gene. There was notumor developed after injection of 5×10~5 IL2-transfectedB16 cells into C57BL/6 mice. However when the

关 键 词：melanoma INTERLEUKIN interferon CLONE MURINE PARENTAL INTERLEUKIN stably immunity cytokine 

分 类 号：R730.3[医药卫生—肿瘤]