MURINE

作品数：537被引量：1420H指数：15
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Targeting MDM2-p53 interaction for breast cancer therapy
《Oncology Research》2025年第4期851-861,共11页AMJAD YOUSUF NAJEEB ULLAH KHAN 
Breast cancer is a significant global concern,with limited effective treatment options.Therefore,therapies with high efficacy and low complications,unlike the existing chemotherapies,are urgently required.To address t...
关键词：Breast cancer Murine double minute 2 proto-oncogene(MDM2) Tumor protein 53(TP53) Targeted therapy 
A murine model of aortic regurgitation generated by transapical wire destruction of the aortic valve
《Animal Models and Experimental Medicine》2025年第3期493-500,共8页Xiaoxia Huang Qiancheng Wang Dan Han Hairuo Lin Zhihong Li Cankun Zheng Jianping Bin Wangjun Liao Zhanchun Cong Mengjia Shen Yulin Liao 
Natural Science Foundation of Guangdong Province,Grant/Award Number:2023A1515110032 and 2022A1515220152;Guangzhou Key Research and Development Program Foundation,Grant/Award Number:202206010199;National Natural Science Foundation of China,Grant/Award Number:82100407,82272602 and 82370242。
Background:The mechanisms underlying cardiac remodeling in aortic valvular(AoV)disease remain poorly understood,partially due to the insufficiency of appropriate preclinical animal models.Here,we present a novel murin...
关键词：animal model aortic regurgitation eccentric hypertrophy heart failure volume overload 
Deep imaging of LepR^(+)stromal cells in optically cleared murine bone hemisections
《Bone Research》2025年第1期104-120,共17页Yuehan Ni Jiamiao Wu Fengqi Liu Yating Yi Xiangjiao Meng Xiang Gao Luyi Xiao Weiwei Zhou Zexi Chen Peng Chu Dan Xing Ye Yuan Donghui Ding Ge Shen Min Yang Ronjie Wu Ling Wang Luiza Martins Nascentes Melo Sien Lin Xiaoguang Cheng Gang Li Alpaslan Tasdogan Jessalyn M.Ubellacker Hu Zhao Shentong Fang Bo Shen 
National Natural Science Foundation of China(grant number 82272563 to B.S.);National Science and Technology Major Project of the Ministry of Science and Technology of China(grant number 2023ZD0501202 to B.S.);institutional grants allocated to the National Institute of Biological Sciences,Beijing(NIBS)from the Chinese Ministry of Science and Technology,Beijing Municipal Commission of Science and Technology,and Tsinghua University;the support from China Pharmaceutical University(grant number 3150140001 to S.F.);National Natural Science Foundation of China(grant numbers 82203653 to S.F.,82371957 to L.W.,and 82371956 to X.C.);Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(grant number JYY2023-8 to X.C.);Research Grants Council of University Grants Committee Hong Kong(grant numbers 14113723,14108720,14121721,14202920,N_CUHK472/22,C7030-18G,T13-402/17-N,and AoE/M-402/20)。
Tissue clearing combined with high-resolution confocal imaging is a cutting-edge approach for dissecting the three-dimensional(3D)architecture of tissues and deciphering cellular spatial interactions under physiologic...
关键词：TRANSPARENT SECTIONS STRAIGHT 
Loss of Arhgap39 facilitates cell migration and invasion in murine hepatocellular cancer cells
《Oncology Research》2025年第2期493-503,共11页HUNG-WEI LIN PEI YU LEE YU-SHIUAN CHANG MAU-SUN CHANG 
supported by Academia Sinica(#20020)to MSC.
Background:Rho GTPases are essential regulators for cellular movement and intracellular membrane trafficking.Their enzymatic activities fluctuate between active GTP-bound and inactive GDP-bound states regulated by GTP...
关键词：Arhgap39 Hepa1-6 Hepa-1c1c7 INVASION 
Enhanced protective effect of selenium-biofortified peptide RYNA(Se)MNDYT compared with its native peptide RYNAMNDYT in lipopolysaccharide-injured murine gut microbiota
《Food Science and Human Wellness》2024年第6期3391-3402,共12页Shujian Wu Zhenjun Zhu Mengfei Chen Aohuan Huang Yizhen Xie Jiaming Chen Liang Xue Moutong Chen Jumei Zhang Juan Wang Qingping Wu Yu Ding 
Guangzhou Basic and Applied Basic Research Project(202201010197);State Key Laboratory of Applied Microbiology Southern China(SKLAM011-2021);National Natural Science Foundation of China(32202014),Guangdong Provincial Key Laboratory(2020B121201009);Guangdong Province Academy of Sciences Special Project for Capacity Building of Innovation Driven Development(2020GDASYL-20200401002).
Selenopeptides may be a valuable bioactive compound to promote gut microbiota-targeted therapeutic methods for intestinal disease and hepatopathy.However,limited information is available on the utilization of selenope...
关键词：Selenopeptide Gut microbiota Metabolites Selenium biofortification Proteomics 
An overview of different methods to establish a murine premature ovarian failure model
《Animal Models and Experimental Medicine》2024年第6期835-852,共18页Negar Pouladvand Mahnaz Azarnia Hadis Zeinali Rouhollah Fathi Somayeh Tavana 
Premature ovarian failure(POF)is defined as the loss of normal ovarian function before the age of 40 and is characterized by increased gonadotropin levels and decreased estradiol levels and ovarian reserve,often leadi...
关键词：animal model chemotherapy drugs MOUSE ovarian damage ovarian reserve premature ovarian failure 
Loss of homeostatic functions in microglia from a murine model of Friedreich's ataxia
《Genes & Diseases》2024年第6期60-64,共5页Ilaria Della Valle Martina Milani Simona Rossi Riccardo Turchi Flavia Tortolici Valentina Nesci Alberto Ferri Cristiana Valle Daniele Lettieri-Bar-bato Katia Aquilano Mauro Cozzolino Savina Apolloni Nadia D'Ambrosi 
funded by the National Ataxia Foundation (NAF)and Friedreich's Ataxia Research Alliance (FARA) (n°821396[RG])to Nadia D'Ambrosi;by Next Generation EU PRIN PNRR 2022 (N°P2022JKTWH)to Nadia D'Ambrosi and Mauro Cozzolino,by FARA Research Grant 2019 to Katia Aquilano;by FARA Research Grant 2021 to Daniele Lettieri-Barbato.
Friedreich's ataxia(FRDA)is a rare genetic disorder characterized by motor discoordination and cerebellar involvement due to mutations in the frataxin(FXN)gene,which encodes a mitochondrial protein involved in ironsul...
关键词：INVOLVEMENT DEGENERATION Friedreich 
Effects of triggers of senescence and senolysis in murine pancreatic cancer cells
《Hepatobiliary & Pancreatic Diseases International》2024年第6期628-637,共10页Denis Revskij Aline Woitas Bianca Kölle Camilla Umstätter Dietmar Zechner Faiz M Khan Georg Fuellen Robert Jaster 
supported by a grant from the Bundesministerium fur Bildung und Forschung(01ZX1903A).
Background:The combination of senescence triggers with senolytic drugs is considered a promising new approach to cancer therapy.Here,we studied the efficacy of the genotoxic agent etoposide(Eto)and irradiation in indu...
关键词：Pancreatic cancer Panc02 cells ETOPOSIDE IRRADIATION Navitoclax 
Celastrus orbiculatus Extract Inhibits Immune Inflammatory Thrombotic State of B-Lymphoma
《Chinese Journal of Integrative Medicine》2024年第11期1018-1026,共9页ZHU Miao SHI Qing-qing NI Jun WU Wei SUN Xing SUN Mei XU Kai-lin LIU Yan-qing GU Jian GU Hao 
Supported by Chinese and Western Medicine Cooperation Project of Subei People's Hospital(No.ZXXTGG2022BO3);Jiangsu Graduate Scientific Research Innovation Program(No.SJCX22 1813)。
Objective:To investigate the inhibitory effect of Celastrus orbiculatus extracts(COE)on the proliferation of lymphoma cells and the immune regulation ability on inflammation and thrombophilia in vivo.Methods:The 38B9 ...
关键词：Celastrus orbiculatus extract murine lymphoma cells tumor inflammation thrombotic state immune regulation proliferation inhibition LYMPHOMA 
β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model
《Bioactive Materials》2024年第9期273-286,共14页Anna Laura Nelson Chiara Mancino Xueqin Gao Joshua AChoe Laura Chubb Katherine Williams Molly Czachor Ralph Marcucio Francesca Taraballi John P.Cooke Johnny Huard Chelsea Bahney Nicole Ehrhart 
supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases(NIAMS)of the National Institutes of Health(NIH)under award number R01 AR077761;support from the Musculoskeletal Regeneration Partnership Fund by Mary Sue and Michael Shannon and by Project Number 20-166 from the Orthoregeneration Network for Kick-Starter Grant;supported by the National Institute on Aging of the National Institutes of Health under Award Number F30AG077748 and the University of Wisconsin-Madison Medical Scientist Training Program:T32GM140935.All content is solely the responsibility of the authors and does not represent the official views of National Institutes of Health,Orthoregeneration Network or Shannon Foundation.
Fractures continue to be a global economic burden as there are currently no osteoanabolic drugs approved to accelerate fracture healing.In this study,we aimed to develop an osteoanabolic therapy which activates the W...
关键词：Gene therapy Fracture healing Lipid nanoparticles MRNA Canonical Wnt 
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