MURINE

作品数：533被引量：1411H指数：15
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相关机构：北京大学温州医学院附属眼视光医院第四军医大学西京医院南京医科大学更多>>
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A murine model of aortic regurgitation generated by transapical wire destruction of the aortic valve
《Animal Models and Experimental Medicine》2025年第3期493-500,共8页Xiaoxia Huang Qiancheng Wang Dan Han Hairuo Lin Zhihong Li Cankun Zheng Jianping Bin Wangjun Liao Zhanchun Cong Mengjia Shen Yulin Liao 
Natural Science Foundation of Guangdong Province,Grant/Award Number:2023A1515110032 and 2022A1515220152;Guangzhou Key Research and Development Program Foundation,Grant/Award Number:202206010199;National Natural Science Foundation of China,Grant/Award Number:82100407,82272602 and 82370242。
Background:The mechanisms underlying cardiac remodeling in aortic valvular(AoV)disease remain poorly understood,partially due to the insufficiency of appropriate preclinical animal models.Here,we present a novel murin...
关键词：animal model aortic regurgitation eccentric hypertrophy heart failure volume overload 
Enhanced protective effect of selenium-biofortified peptide RYNA(Se)MNDYT compared with its native peptide RYNAMNDYT in lipopolysaccharide-injured murine gut microbiota
《Food Science and Human Wellness》2024年第6期3391-3402,共12页Shujian Wu Zhenjun Zhu Mengfei Chen Aohuan Huang Yizhen Xie Jiaming Chen Liang Xue Moutong Chen Jumei Zhang Juan Wang Qingping Wu Yu Ding 
Guangzhou Basic and Applied Basic Research Project(202201010197);State Key Laboratory of Applied Microbiology Southern China(SKLAM011-2021);National Natural Science Foundation of China(32202014),Guangdong Provincial Key Laboratory(2020B121201009);Guangdong Province Academy of Sciences Special Project for Capacity Building of Innovation Driven Development(2020GDASYL-20200401002).
Selenopeptides may be a valuable bioactive compound to promote gut microbiota-targeted therapeutic methods for intestinal disease and hepatopathy.However,limited information is available on the utilization of selenope...
关键词：Selenopeptide Gut microbiota Metabolites Selenium biofortification Proteomics 
An overview of different methods to establish a murine premature ovarian failure model
《Animal Models and Experimental Medicine》2024年第6期835-852,共18页Negar Pouladvand Mahnaz Azarnia Hadis Zeinali Rouhollah Fathi Somayeh Tavana 
Premature ovarian failure(POF)is defined as the loss of normal ovarian function before the age of 40 and is characterized by increased gonadotropin levels and decreased estradiol levels and ovarian reserve,often leadi...
关键词：animal model chemotherapy drugs MOUSE ovarian damage ovarian reserve premature ovarian failure 
Loss of homeostatic functions in microglia from a murine model of Friedreich's ataxia
《Genes & Diseases》2024年第6期60-64,共5页Ilaria Della Valle Martina Milani Simona Rossi Riccardo Turchi Flavia Tortolici Valentina Nesci Alberto Ferri Cristiana Valle Daniele Lettieri-Bar-bato Katia Aquilano Mauro Cozzolino Savina Apolloni Nadia D'Ambrosi 
funded by the National Ataxia Foundation (NAF)and Friedreich's Ataxia Research Alliance (FARA) (n°821396[RG])to Nadia D'Ambrosi;by Next Generation EU PRIN PNRR 2022 (N°P2022JKTWH)to Nadia D'Ambrosi and Mauro Cozzolino,by FARA Research Grant 2019 to Katia Aquilano;by FARA Research Grant 2021 to Daniele Lettieri-Barbato.
Friedreich's ataxia(FRDA)is a rare genetic disorder characterized by motor discoordination and cerebellar involvement due to mutations in the frataxin(FXN)gene,which encodes a mitochondrial protein involved in ironsul...
关键词：INVOLVEMENT DEGENERATION Friedreich 
Effects of triggers of senescence and senolysis in murine pancreatic cancer cells
《Hepatobiliary & Pancreatic Diseases International》2024年第6期628-637,共10页Denis Revskij Aline Woitas Bianca Kölle Camilla Umstätter Dietmar Zechner Faiz M Khan Georg Fuellen Robert Jaster 
supported by a grant from the Bundesministerium fur Bildung und Forschung(01ZX1903A).
Background:The combination of senescence triggers with senolytic drugs is considered a promising new approach to cancer therapy.Here,we studied the efficacy of the genotoxic agent etoposide(Eto)and irradiation in indu...
关键词：Pancreatic cancer Panc02 cells ETOPOSIDE IRRADIATION Navitoclax 
Celastrus orbiculatus Extract Inhibits Immune Inflammatory Thrombotic State of B-Lymphoma
《Chinese Journal of Integrative Medicine》2024年第11期1018-1026,共9页ZHU Miao SHI Qing-qing NI Jun WU Wei SUN Xing SUN Mei XU Kai-lin LIU Yan-qing GU Jian GU Hao 
Supported by Chinese and Western Medicine Cooperation Project of Subei People's Hospital(No.ZXXTGG2022BO3);Jiangsu Graduate Scientific Research Innovation Program(No.SJCX22 1813)。
Objective:To investigate the inhibitory effect of Celastrus orbiculatus extracts(COE)on the proliferation of lymphoma cells and the immune regulation ability on inflammation and thrombophilia in vivo.Methods:The 38B9 ...
关键词：Celastrus orbiculatus extract murine lymphoma cells tumor inflammation thrombotic state immune regulation proliferation inhibition LYMPHOMA 
β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model
《Bioactive Materials》2024年第9期273-286,共14页Anna Laura Nelson Chiara Mancino Xueqin Gao Joshua AChoe Laura Chubb Katherine Williams Molly Czachor Ralph Marcucio Francesca Taraballi John P.Cooke Johnny Huard Chelsea Bahney Nicole Ehrhart 
supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases(NIAMS)of the National Institutes of Health(NIH)under award number R01 AR077761;support from the Musculoskeletal Regeneration Partnership Fund by Mary Sue and Michael Shannon and by Project Number 20-166 from the Orthoregeneration Network for Kick-Starter Grant;supported by the National Institute on Aging of the National Institutes of Health under Award Number F30AG077748 and the University of Wisconsin-Madison Medical Scientist Training Program:T32GM140935.All content is solely the responsibility of the authors and does not represent the official views of National Institutes of Health,Orthoregeneration Network or Shannon Foundation.
Fractures continue to be a global economic burden as there are currently no osteoanabolic drugs approved to accelerate fracture healing.In this study,we aimed to develop an osteoanabolic therapy which activates the W...
关键词：Gene therapy Fracture healing Lipid nanoparticles MRNA Canonical Wnt 
Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model
《Neuroscience Bulletin》2024年第8期1037-1052,共16页Chenrui Yin Kefei Luo Xinyue Zhu Ronghang Zheng Yu Wang Guangdan Yu Xiaorui Wang Fei She Xiaoying Chen Tao Li Jingfei Chen Baduojie Bian Yixun Su Jianqin Niu Yuxin Wang 
supported by grants from the National Nature Science Foundation of China(32271034,32070964,82301703,32300791,and 81901378);Science and Technology Innovation Enhancement Project of Army Medical University(2022XQN40);National Key Research and Development Program of China(2021ZD0201703);Chongqing Natural Science Fund for Distinguished Young Scholars(CSTB2023NSCQ-JQX0030);Undergraduate Research Cultivation Project of Army Medical University(2020XBK16);Guangdong Basic and Applied Basic Research Foundation(2021A1515110268 and 2023A1515010651);Shenzhen Fundamental Research Program(RCBS20210706092411028 and JCYJ20210324121214039).
Posttraumatic stress disorder(PTSD)is a complex mental disorder notable for traumatic experience memory.Although current first-line treatments are linked with clinically important symptom reduction,a large proportion ...
关键词：PTSD Fear memory MYELINATION Oligodendroglial differentiation FLUOXETINE Wnt signaling 
Intermittent fasting boosts antitumor immunity by restricting CD11b^(+)Ly6C^(low)Ly6G^(low) cell viability through glucose metabolism in murine breast tumor model
《Food Science and Human Wellness》2024年第4期2327-2345,共19页Chenghao Fu Zhehao Liang Zemiao Niu Ning Chen Yuemin Li Zhenhua Liang Yanwei Huo Hao Xi Rong Wang Yonghuan Yan Xiaoruo Gan Mengtian Wang Yun Huang Yan Zhang Mingming Gao Pin Lü 
supported by the Postdoctoral Research Funds of Hebei Medical University(30705010016-3759);Natural Science Foundation of China(32272328);Natural Science Foundation of Hebei Province(B2022321001);National Key Research Project of Hebei Province(20375502D);Postdoctoral Research Project of Hebei Province(B2022003031);Science and Technology Research Program of Hebei Provincial Colleges(QN2023229);Hebei Provincial Key Laboratory of Nutrition and Health(2023YDYY-KF05)。
Intermittent fasting can benefit breast cancer patients undergoing chemotherapy or immunotherapy.However,it is still uncertain how to select immunotherapy drugs to combine with intermittent fasting.Herein we observed ...
关键词：Intermittent fasting Ly6G^(low)myeloid-derived suppressor cell apoptosis Extramedullary hematopoiesis Colony stimulating factor Glucose metabolism restriction 
Exploring the effects of taurolidine on tumor weight and microvessel density in a murine model of osteosarcoma
《Oncology Research》2024年第7期1163-1172,共10页LISANNE K.A.NEIJENHUIS LEUTA L.NAUMANN SONIA A.M.FERKEL SAMUEL J.S.RUBIN STEPHAN ROGALLA 
Background:Osteosarcoma is the most common malignant primary bone tumor.The prognosis for patients with disseminated disease remains very poor despite recent advancements in chemotherapy.Moreover,current treatment reg...
关键词：OSTEOSARCOMA TAUROLIDINE Cancer treatment CHEMOTHERAPY Murine models 
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