Lack of correlation between rejection of tumor cells co-expresssing interleukin-2 and B7.1 and vaccine efficiency  

作　　者：G.Richter S.Cayeux C.Becker C.Beck A.Aicher B.Drken T.Blankenstein 

机构地区：[1]Max-Delbrck-Center for Molecular Medicine,Robert-Rssle-Strasse 10,13122 Berlin,Robert-Rssle Klinik,Freie Universitt Berlin,Lindenberger Weg 80,13125 Berlin,Gernmany,Max-Delbrck-Center for Molecular Medicine,Robert-Rssle-Strasse 10,13122 Berlin,Max-Delbrck-Center for Molecular Medicine,Robert-Rssle-Strasse 10,13122 Berlin,Max-Delbrck-Center for Molecular Medicine,Robert-Rssle-Strasse 10,13122 Berlin,Robert-Rssle Klinik,Freie Universitt Berlin,Lindenberger Weg 80,13125 Berlin,Gernmany,Max-Delbrck-Center for Molecular Medicine,Robert-Rssle-Strasse 10,13122 Berlin

出　　处：《中国实验血液学杂志》1997年第3期315-316,共2页Journal of Experimental Hematology

摘　　要：Gene modification of tumor cells to express a varietyof cytokines such as IL-2 or the co-stimulatory moleculeB7. 1 led to increased immunogenicity and reducedtumorigenicity of tumors has several models and thisprocess involves T cells. We have previously reporteddecreased tumorigenicity of the murine plasmacytomaJ558L (MHC class Ⅰ^+ and class Ⅱ^-) expressing IL-2 orB7. l. When systemic immunity was analyzed,

关 键 词：REJECTION INTERLEUKIN vaccine immunity expressing cytokines immunized comparable NUDE alone 

分 类 号：R730.3[医药卫生—肿瘤]