Molecular basis of the adhesive process of polymorphonuclear neutrophils to vascular endothelial cells under endotoxin condition  

Molecular basis of the adhesive process of polymorphonuclear neutrophils to vascular endothelial cells under endotoxin condit

作　　者：周向东 陈意生 史景泉 

出　　处：《Journal of Medical Colleges of PLA(China)》1996年第3期161-163,共3页中国人民解放军军医大学学报（英文版）

摘　　要：The monocellular adhesive ability of polymorphonuclear neutrophils (PMN)to vascular endothelial cells (VEC) was observed with micromanipulation technique when the cells were treated with endotoxin, Anti-CD18 monoclonal antibodies (McAb),anti-endothelial-leucocytic adhesion molecule-l (ELAM-l)McAb and anti-intercellular adhesion molecule-1 (ICAM-1) McAb and the effects of these 3 adhesion molecules on the development of adhesion force between PMNs and VECs were investigated. It was found that CD18 McAb decreased obviously the adhesive ability of PMNs in the whole course of adhesion increasing and the McAbs of ELAM-1 and ICAMI-1 inhibited most of adhesive force of VECs in the 4th and 12th hour of the course respectively.These findings suggest that the main molecular basis of rapid increase of adhesive ability of PMNs is CD18 expression and that of delayed increase of adhesive ability of VECs is ELAM-1 and ICAM-1 expression.

关 键 词：ENDOTOXIN POLYMORPHONUCLEAR NEUTROPHIL ENDOTHELIAL cell ADHESION MOLECULE 

分 类 号：R331.142[医药卫生—人体生理学]