异基因骨髓移植治疗成人急性白血病(附3例报告)  

Treatment of adult acute leukemia with allogenic bone marrow transplantation(BMT)

作　　者：刘海川[1] 姚善谦[1] 彭矞云[1] 吕善根[1] 楼方定[1] 汪月增[1] 曾狄闻[1] 王连元[1] 刘景汉[1] 张祥麟 刘作斌[1] 王月峰 张尊一 谭汉君[1] 李次芬[1] 崔宝印[1] 李祥[1] 孙志贤[2] 孔繁华[2] 田丁[3] 

机构地区：[1]解放军总医院 [2]军事医学科学院 [3]北京医科大学血研所

出　　处：《解放军医学院学报》1989年第1期5-8,共4页Academic Journal of Chinese PLA Medical School

摘　　要：近十余年来,异基因骨髓移植治疗白血病取得了令人鼓舞的效果利用移植前对患者采用大剂量化疗和全身放射治疗,以及移植骨髓的抗白血病作用,已使移植后有50～70％白血病患者。获得长期缓解或治愈。Three patients with acute leukaemia had undergone BMT since April 1985. In two cases who received BMT during their first remission long term engraftment was achieved as evidenced by the presence of dornors' blood group and karyotype. They lived in a disease-free state for more than 24 and 6 months respectively, and are still alive. The third one was treated in the 2nd remission and died of severe GVHD on+23 day. She also showed donor's sex chromosome on 15 days after BMT.Fractional TBI seems to be better than single TBI, because of its low incidence of interstitial pneumonia and other side effects. The effects of Cyclosporin A+MTX and MTX+Prednisone+r-globulin in the prevention of GVHD was compared, the formor being more effective but expensive, while the latter being less expensive and more easily accepted by the patients.

关 键 词：异基因骨髓移植 急性白血病 抗白血病作用 大剂量化疗 GVHD 全身照射 植活 移植物抗宿主病 胎盘丙种球蛋白 环磷酞胺 

分 类 号：R82[医药卫生—临床医学]