多奈哌齐治疗阿尔茨海默病患者认知功能的自然观察研究  

Naturalistic observation of the effect of donepezil on cognitive function in Alzheimer＇s disease in memory clinic

作　　者：林凯[1] 于欣[1] 王华丽[1] 

机构地区：[1]北京大学精神卫生研究所记忆障碍诊疗与研究中心卫生部精神卫生学重点实验室,100191

出　　处：《中国综合临床》2009年第4期345-347,共3页Clinical Medicine of China

基　　金：国家自然基金（30500178）志谢：本研究得到国家自然科学基金（30500178）和美国阿尔茨海默病协会研究基金（NIRG-04-1184）的部分支持.感谢Evelyn Teng（李眉）教授馈赠CASI量表以及测查指导手册,感谢赵学英老师进行大量的认知测查工作.感谢所有参加研究的患者及其家属的志愿参与和热忱支持.

摘　　要：目的 考察记忆门诊自然观察过程中多奈哌齐对阿尔茨海默病（AD）患者认知功能的改善作用。方法13例在记忆门诊就诊的符合NINCDS—ADRDA很可能AD诊断标准的接受多奈哌齐（5mg／d）治疗的轻中度AD患者纳入自然观察研究，采用认知功能筛查测验（CASI）评估患者认知功能，分别在治疗前、治疗3个月和6个月进行。结果与基线相比，治疗6个月时思维流畅性有显著改善（4．3±3．1与6．2±2．7，P〈0．05）；构图能力呈改善趋势，但差异无统计学意义（P=0．06），其余认知功能治疗前后比较差异均无统计学意义（P均〉0．05）。结论记忆门诊自然观察条件下，多奈哌齐能改善AD患者言语流畅性，并能使患者其他认知领域功能保持基本稳定。Objective To examine the effect of donepezil on cognitive function of Alzheimer＇s disease from a naturalistic observation in memory clinic. Methods From the subject pool in memory clinic, thirteen patients with mild to moderate Alzheimer＇s disease （meeting NINCDS-ADRDA criteria of probable AD） were enrolled in the naturalistic observation. Donepezil with dosage of 5 mg daily was administered. Cognitive Ability Screening Instrument （CASI） was used to assess the cognitive function, and was administered at baseline ,3 and 6 months after treatment with donepezil. Results After 6-month treatment with donepezil, the change of score of verbal fluency from baseline was significant [ （4.3 ±3.1 ） vs （6.2 ±2.7） ,P 〈0.05]. There was a trend that constructional praxis was also improved after 6-month treatment （ P = 0.06 ）. The change of scores of other cognitive domains remained the same（ P 〉 0.05）. Conclusion In the naturalistic observation at memory clinic, donepezil may improve verbal fluency of AD patients, and keep most cognitive function stable.

关 键 词：多奈哌齐 阿尔茨海默病 认知功能 自然观察 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R749.3[医药卫生—临床医学]