大豆异黄酮对良性前列腺增生大鼠抗氧化作用的研究  

Study on Antioxidation of Soybean Isoflavone on Benign Prostatic Hyperplasia of Rats

作　　者：姜伟伟[1] 任国峰[1] 杨爱青[1] 汤凌[1] 黄忆明[1] 

机构地区：[1]中南大学公共卫生学院营养与食品卫生系,湖南长沙410078

出　　处：《食品科学》2009年第7期233-235,共3页Food Science

基　　金：国家自然科学基金面上项目(30500407)

摘　　要：目的:本研究探讨补充不同剂量大豆异黄酮对大鼠前列腺增生的影响,并初步探讨大豆异黄酮的抗氧化作用与抑制前列腺增生的关系。方法:应用丙酸睾酮诱导大鼠前列腺增生,观察正常对照组、模型组、低、中、高剂量大豆异黄酮组大鼠前列腺的湿重、前列腺指数、前列腺组织匀浆中TAOC、GSH、CAT、SOD等各项抗氧化指标和MDA水平的改变。结果:低、中、高剂量组大鼠前列腺湿重及前列腺指数均显著低于模型组(p<0.05);与模型组相比,低中高剂量组的CAT、TAOC、SOD、GSH显著升高,而MDA显著降低(p<0.05)。中剂量组效果最为明显。结论:大豆异黄酮可以显著抑制大鼠前列腺增生,明显提高大鼠的抗氧化能力。大豆异黄酮可能对预防和辅助治疗前列腺增生有一定的作用。Objectives： To explore the inhibitive effect of different dosages of soybean isoflavone on benign prostatic hyperplasia of rats and the relationship between the antioxidation of soybean isoflavone and the inhibition of benign prostatic hyperplasia. Methods： The prostate hyperplasia of rats was induced by subcutaneous injection with testosterone propionate, and the changes of prostate wet weight, prostatic index, total antioxidation capacity （TAOC）, activities of catalase （CAT）, superoxide dismutase （SOD）, glutathione peroxidase （GSH）, and level of maleic dialdehyde （MDA） of prostate tissue in the control, the model and the soybean isoflavone （low, moderate and high doses, respectively） groups were observed. Results： The prostate wet weight, prostatic index and MDA level in all soybean isoflavone groups are significantly lower than those in the model group （p 〈 0.05）, while CAT, TAOC, SOD and GSH in all soybean isoflavone groups are significantly higher than those in the model group, especially the effect of moderate dose is the most obvious. Conclusion： Soybean isoflavone may effectively inhibit the development of prostate hyperplasia and promote the antioxidation of rats. Therefore, soybean isoflavone may serve as the supplementary therapy and prevention for benign prostatic hyperplasia.

关 键 词：大豆异黄酮 前列腺增生 抗氧化作用 

分 类 号：R153.3[医药卫生—营养与食品卫生学]