DNA修复基因XRCC1单核苷酸多态性与非霍奇金淋巴瘤遗传易感性的关系  

Polymorphisms of DNA repair genes XRCC1 and susceptibility to non-Hodgkin lymphoma

作　　者：任丽娟[1] 张巧花[2] 施静艺[3] 张群岭[3] 姜晓星[3] 侯淑玲[2] 黄云鹏[2] 赵维莅[3] 

机构地区：[1]山西医科大学研究生处,太原030001 [2]山西省肿瘤医院血液内科 [3]上海交通大学附属瑞金医院、上海血液学研究所

出　　处：《白血病．淋巴瘤》2009年第4期197-200,共4页Journal of Leukemia & Lymphoma

基　　金：基金项目：国家高技术研究发展计划（2006AA02A301）;教育部新世纪优秀人才支持计划、国家自然科学基金（30750335）;霍英东青年教师基金（111035）

摘　　要：目的探讨DNA修复基因XRCC1 R280H、XRCC1 TSS＋29C／T单核苷酸多态性与非霍奇金淋巴瘤（NHL）易感性的关系。方法运用MassARRAY技术对73例NHL病例和540名健康对照的DNA修复基因XRCC1多态性进行检测，比较其不同基因型与淋巴瘤患病风险的关系。结果XRCC1R280H中G、A基因频率在对照组和病例组中分布差异有统计学意义（P=0．001），而XRCC1TSS＋29C／T中T、C的基因频率在两组中的分布差异无统计学意义（P：0．383）。进一步的分析表明，在XRCC1R280H中，与携带GG野生纯合子基因型者比较，携带至少一个A等位基因者（GA或AA）患淋巴瘤的风险显著降低（P〈0．001，OR=0．309，95％CI=0．168—0．567）。而在XRCC1TSS＋29C／T中，CC和CT与基因TT比较，携带c基因者会增加淋巴瘤的发病风险（P=0．472，OR=1．262，95％口=0．669～2．379）。结论DNA修复基因XRCC1R280H的基因多态性与NHL的发生密切相关。Objective To investigate the correlation between XRCC1 R280H,XRCC1 TSS＋29C/T genetic polymorphisms and susceptibility to non-Hodgkin lymphoma （NHL）. Methods The MassARRAY method was applied to detect the DNA repair gene XRCC1 genetic polymorphisms in 73 cases of NHL and 540 cases of normal healthy controls. Chi-square test was performed to calculate the adjusted odds ratios （OR） and 95% confidence intervals （CI）. Results For XRCC1 R280H genotypes, there was a significant difference between frequencies of the G and A among patients and controls （P =0.001）. However, XRCC1 TSS＋29C/T gcnotypes had no statistical difference as for the T and C frequencies between patients and controls （P = 0.383）. The frequency of XRCC1 R280H with at least one A genotype was lower in the NHL cases than in controls, indieating＇a decreased risk for NHL development （OR =0.309, 95 % CI =0.168-0.567）, comparing with GG genotype. In XRCC1 TSS＋29C/T genotypes, the frequency of TC and CC genotype was higher in NHL cases than in controls and associated with an increased risk of NHL development （P =0.472, OR =1.262, 95 % CI =0.669-2.379）. Conclusion DNA repair XRCC1 gene possesses significant correlation with NHL.

关 键 词：淋巴瘤 非霍奇金 多态性 单核苷酸 易感性 XRCC1 

分 类 号：R733[医药卫生—肿瘤]