MAGE-A3基因与MDR1基因在非M3型急性白血病患者中的表达及其临床意义  

Expression of MAGE-A3 Gene and MDR1 Gene in Non M3-subtype Acute Leukemia and their correlations to clinical treatment efficacy

作　　者：黎国伟[1] 王东宁[2] 吴红梅[1] 余相[1] 许先吟[1] 

机构地区：[1]广东省惠州市中心人民医院血液科,广东惠州516001 [2]中山大学附属第三医院血液科

出　　处：《中国医师杂志》2009年第4期474-476,共3页Journal of Chinese Physician

基　　金：广东省惠州市科技计划资助项目（2007Y002）

摘　　要：目的观察MAGE-A3与MDR1在非M3型急性白血病（AL）患者中的表达及其与治疗反应的关系。方法应用逆转录-聚合酶链反应法观察77例初治非M3型AL患者MAGE-A3和MDR1的表达，结合临床观察。结果MAGE-A3及MDR1在非M3型AL患者中表达阳性率分别为50．6％与23．3％。MAGE-A3表达阳性与阴性者MDR1阳性率分别为46．2％与13．2％（P〈0．01）。MAGE-A3表达阴性与阳性者治疗完全缓解（CR）率分别为86．8％与64．1％（P〈0．05）；MDR1表达阴性与阳性者CR率分别为83．3％与56．5％（P〈0．05）。MAGE-A3和MDR1表达均为阳性者与均为阴性CR率分别为55．6％与87．9％（P〈0．05）。结论非M3型AL MAGE-A3表达阳性者MDRI有较高的表达率，MAGE-A3及MDR1表达均为阴性者治疗缓解率高。提示联合检测MAGE，A3和MDR1对判断初治非M3型AL的疗效有良好的预测作用，可作为临床判断疗效的一项有意义的指标。Objective To evaluate the clinical value of co-observation of the expression of MAGE-A3 gene and MDR1 gene on estimating the curative effect in non M3-subtype acute leukemia. Methods Expressions of MAGE-A3 and MDR1 were measured in 77 patients with non M3-subtype acute leukemia by RT-PCR method. Clinical observation was done to estimate the relationship between the genes with curative effect in non M3-subtype acute leukemia. Results Expression of MAGE-A3 and MDR1 gene were 50. 6% and 23.3% in non M3-subtype acute leukemia patients. Positive expression of MDR1 in MAGE-A3-positive and negative patients were 46. 2% and 13.2% （ P 〈 0.01 ）. The complete remission rate in MAGE-A3 negative and positive patients were 86. 8% and 64. 1% （ P 〈 0. 05）. Complete remission （CR） rate in MDR1 negative and positive patients was 83.3% and 56. 5% （ P 〈0. 05）. Complete remission rate were 87.9% and 55.6% in both negative and both positive expression of MAGE-A3 and MDR1 （ P 〈 0.05）. Conclusion The patients of positive expression of MAGE-A3 in non M3-subtype AL had higher expression of MDR1. The patients with negative expression of both MAGE-A3 and MDR1 had higher CR rate than that in both positive patients. These researches indicated that co-observation of the expression of MAGE-A3 and MDR1 can predict the curative effect in non M3-subtype AL.

关 键 词：肿瘤蛋白质类 基因 MDR 白血病 

分 类 号：R733[医药卫生—肿瘤]