银杏外种皮多糖的免疫活性研究  

Effects of the Crude Polysaccharides from Ginkgo biloba Sarcotesta on Immune Function in Mice

作　　者：仰榴青[1] 茆广华[2] 吴向阳[3] 范群艳[2] 朱小宦[2] 

机构地区：[1]江苏大学药学院,江苏镇江212013 [2]江苏大学食品与生物工程学院,江苏镇江212013 [3]江苏大学化学化工学院,江苏镇江212013

出　　处：《时珍国医国药》2009年第4期872-873,共2页Lishizhen Medicine and Materia Medica Research

基　　金：江苏省天然药物研究与创制实验室开放课题(No.KF2005005);江苏省镇江市科技计划项目(No.NY2005037);江苏大学高级技术人才科研启动基金项目(No.04JDG030)

摘　　要：目的研究脱蛋白和未脱蛋白银杏外种皮粗多糖(GBEP)对免疫功能低下小鼠的免疫调节作用。方法采用药物方法建立免疫抑制小鼠动物模型,利用腹腔巨噬细胞吞噬鸡红细胞实验、血清溶血素抗体生成实验及脏器系数的变化,研究银杏外种皮粗多糖对免疫抑制小鼠免疫功能的影响。结果银杏外种皮粗多糖可增强免疫抑制小鼠的腹腔巨噬细胞吞噬功能、血清溶血素抗体水平以及能对抗环磷酰胺引起的脾脏萎缩。结论银杏外种皮粗多糖具有增强小鼠免疫功能的作用,脱蛋白粗多糖的免疫活性稍好于未脱蛋白多糖。Objective To study immune regulatory activity of the crude polysaeeharides with or without protein from Ginkgo biloba Sareotesta in immune depressive mice. Methods The model of immune depressive miee was established with eyelophosphamide. The function of macrophage in abdominal activity was measured. Spectrophotometric determination was adopted to evaluate the ability of antibody produeing cell. The index of immune organ was used to observe the changes of immune organg weight. Results It showed the GBEP eould enhance mouse maerophage to swallow chieken erythroeytes, significantly enhaneed the content of haemolysin in mouse body and siguifieantly increased spleen index in immuno suppression miee. Conclusion GBEP can enhance immune function of immune deficient mice, and the crude polysaeeharides without protein has much better immune activity than that with protein.

关 键 词：银杏外种皮 多糖 环磷酰胺 免疫调节 

分 类 号：R151.2[医药卫生—营养与食品卫生学]