子宫颈癌中核转录因子NF-kB的表达及其临床意义  

Study on expression of NF-k B in cervical intraepithelial neoplasia and cervical carcinoma

作　　者：糜若然[1] 瞿全新[2] 黄艳艳[2] 

机构地区：[1]天津医科大学总医院,中国300052 [2]天津市第一中心医院,中国300000

出　　处：《华夏医药》2009年第2期86-89,共4页Hua-xia Medicine

摘　　要：目的研究核转录因子NF-KB在人宫颈癌中的表达，探讨其在宫颈癌发生、进展过程中的作用及临床意义。方法应用免疫组织化学染色方法（S．P）检测宫颈癌组织42例、C1N20例及正常宫颈10例中NF-KB表达水平。结果宫颈癌组织中NF-KB蛋白阳性表达率为74．1％（30／42），CIN组织中NF-KB蛋白阳性表达率为15％（3／20），正常组织中则无NF-KB表达，宫颈癌中NF-KB表达水平高于CIN与正常宫颈组织（P〈0．05）；CIN中NF-KB表达水平与正常宫颈组织间无统计学差异（P〉0．05）。在宫颈癌中，NF-KB表达在低分化，与患者年龄、病理类型无关（P〉0.05），NF-KB不仅高表达于低分化宫颈癌，而且随着临床分期增高、出现淋巴转移等，其表达增强。结论NF-KB不是导致子宫颈癌前病变的主要机制，可能只是表达量的积累过程。而NF-KB异常表达及激活可能是子宫颈癌发生、进展过程中的重要机制之一。Objective To evaluate the signifi- cance of NF-- kB expression in cervical carcinoma. Methods The expression of NF- kB protein was analyzed by immunohistochemistry method. Results There was 74.1%（/42） expression of NF- kB in 42 cases with cervical carcinoma, 15%（/20） in CIN and 0 in normal cervical tissue. Significant differ- ences of NF- kB expression were observed be- tween cervical carcinoma, CIN and normal cervical tissues（P〈0.05）. But there was no significant differ- ences between CIN and normal cervical tissues （P 〉0.05）. In cervical cancers, NF- kB expression was higher in poorly differentiated cases than that in good differentiated cases. NF- kB expression was not associated with age and pathologic types （P 〉0.05）. Conclusion Expression of NF- kB may not be the key mechanism in cervical intraep- ithelial neoplasia, but abnormal expression of NF- kB may be one of the important part mechanisms in the cervical carcinogenesis and progres- sion.

关 键 词：子宫颈癌 子宫颈上皮内瘤样病变 NF-KB 

分 类 号：R737.33[医药卫生—肿瘤]