子宫颈癌中核转录因子NF-kB的表达及其临床意义  

Study on expression of NF-k B in cervical intraepithelial neoplasia and cervical carcinoma

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作  者:糜若然[1] 瞿全新[2] 黄艳艳[2] 

机构地区:[1]天津医科大学总医院,中国300052 [2]天津市第一中心医院,中国300000

出  处:《华夏医药》2009年第2期86-89,共4页Hua-xia Medicine

摘  要:目的研究核转录因子NF-KB在人宫颈癌中的表达,探讨其在宫颈癌发生、进展过程中的作用及临床意义。方法应用免疫组织化学染色方法(S.P)检测宫颈癌组织42例、C1N20例及正常宫颈10例中NF-KB表达水平。结果宫颈癌组织中NF-KB蛋白阳性表达率为74.1%(30/42),CIN组织中NF-KB蛋白阳性表达率为15%(3/20),正常组织中则无NF-KB表达,宫颈癌中NF-KB表达水平高于CIN与正常宫颈组织(P〈0.05);CIN中NF-KB表达水平与正常宫颈组织间无统计学差异(P〉0.05)。在宫颈癌中,NF-KB表达在低分化,与患者年龄、病理类型无关(P〉0.05),NF-KB不仅高表达于低分化宫颈癌,而且随着临床分期增高、出现淋巴转移等,其表达增强。结论NF-KB不是导致子宫颈癌前病变的主要机制,可能只是表达量的积累过程。而NF-KB异常表达及激活可能是子宫颈癌发生、进展过程中的重要机制之一。Objective To evaluate the signifi- cance of NF-- kB expression in cervical carcinoma. Methods The expression of NF- kB protein was analyzed by immunohistochemistry method. Results There was 74.1%(/42) expression of NF- kB in 42 cases with cervical carcinoma, 15%(/20) in CIN and 0 in normal cervical tissue. Significant differ- ences of NF- kB expression were observed be- tween cervical carcinoma, CIN and normal cervical tissues(P〈0.05). But there was no significant differ- ences between CIN and normal cervical tissues (P 〉0.05). In cervical cancers, NF- kB expression was higher in poorly differentiated cases than that in good differentiated cases. NF- kB expression was not associated with age and pathologic types (P 〉0.05). Conclusion Expression of NF- kB may not be the key mechanism in cervical intraep- ithelial neoplasia, but abnormal expression of NF- kB may be one of the important part mechanisms in the cervical carcinogenesis and progres- sion.

关 键 词:子宫颈癌 子宫颈上皮内瘤样病变 NF-KB 

分 类 号:R737.33[医药卫生—肿瘤]

 

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