DMBA诱导大鼠乳腺癌癌前病变动物模型研究概况  

Advances of rat breast precancer models' induced by DMBA

作　　者：李静蔚[1] 宋爱莉[1] 刘晓菲[1] 

机构地区：[1]山东中医药大学附属医院乳腺外科,山东济南250011

出　　处：《中华肿瘤防治杂志》2009年第3期234-237,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:总结国内外对建立乳腺癌癌前病变动物模型研究的现状。方法:应用Medline及CHKD期刊全文数据库检索系统,以"乳腺癌癌前病变、乳腺癌、DM-BA和动物模型"为关键词,检索1961-05-2007-12的相关文献,共检索到英文文献652条,中文文献103条。纳入标准:1)DMBA的致癌机制;2)DMBA诱导乳腺癌癌前病变的动物选择;3)DMBA诱导乳腺癌癌前病变的应用方法;4)DMBA诱导乳腺癌癌前病变的病理形态学特点。根据纳入标准,精选58篇文献,最后纳入分析35篇文献。结果:乳腺癌癌前病变是癌变过程一个必经阶段,目前一般采用化学致癌剂DMBA诱发大鼠乳腺癌发生,在癌变之前及时中止,获取癌前病变动物模型。该造模方法易于复制,结果稳定,与人体癌变过程相似。结论:DMBA诱导大鼠建立乳腺癌癌前病变动物模型是乳腺癌病因学和预防学研究理想的实验方法。OBJECTIVE： To summarize the research status of the animal models of breast precancer. METHODS： A computerbased online search of Medline database and CHKD database was undertaken for literature about breast precancer published from May 1961 to December 2007 with the key words of ＂breast precancer, breast cancer, DMBA,animal models＂, and 652 papers in English and 103 papers in Chinese were searched, respectively. The literature about the animal models of breast precancer was selected after first selection. Selection criteria： 1） the carcinogenesis mechanism of DMBA, 2） the selection of animals, 3） the application methods of DMBA, 4） the pathology character. Hundreds of papers about animal models of breast precancer were collected, and 58 were selected according to the inclusive criteria. Finally, 35 articles were analyzed. RESULTS： Breast precancer was a necessary and conversable phase during the canceration, and its animal model was obtained by inducing with DMBA generally, and stopping halfway in time before canceration. This method was easy in reproducing, steady in results, and similar to human in morphology. CONCLUSION： It is a perfect method for study of breast cancer etiology and prevention by inducing rats with DMBA and reproducing animal models of breast precancer.

关 键 词：乳腺癌癌前病变 动物模型 DMBA 综述文献 

分 类 号：R737.9[医药卫生—肿瘤]