哺乳动物硒蛋白的研究进展  

Progress in the Study of Mammalian Selenoprotein

作　　者：张在香[1] 杨晓光[1] 夏弈明[1] 陈孝曙[1] 

机构地区：[1]中国预防医学科学院营养与食品卫生研究所

出　　处：《生理科学进展》1998年第1期27-34,共8页Progress in Physiological Sciences

摘　　要：硒是哺乳动物和人必需的微量元素。硒的生物学功能主要是以硒蛋白的形式表现的。到目前为止，已经克隆并测定ｃＤＮＡ顺序的哺乳动物硒蛋白有９种，它们是细胞内谷胱甘肽过氧化物酶、细胞外谷胱甘肽过氧化物酶、磷脂氢谷胱甘肽过氧化物酶、胃肠谷胱甘肽过氧化物酶、Ⅰ型碘化甲状腺原氨酸５′脱碘酶、Ⅱ型碘化甲状腺原氨酸５′脱碘酶、Ⅲ型碘化甲状腺原氨酸５′脱碘酶、硒蛋白Ｐ和硒蛋白Ｗ。这些硒蛋白中硒参入到蛋白分子是通过硒半胱氨酸ｔＲＮＡ识别ｍＲＮＡ中特异的ＵＧＡ密码子将硒半胱氨酸插入到硒蛋白中。Selenium is an essential trace element for animals and humans. Selenium exerts its biological function largely through selenoproteins. Up to now nine selenoproteins'cDNAs have been cloned and sequenced, which are cellular glutathione peroxidase(cGPX), extracellular glutathine peroxidase(eGPX), phospholipid hydroperoxidase glutathione peroxidase(PHGPX), gastrointestinal glutathione peroxidase (GPXGI), type Ⅰ iodothyronine 5′deiodinase (IDⅠ),type 2 iodothyronine 5′deiodinase(IDⅡ), type Ⅲ iodothyronine 5deiodinase(IDⅢ), selenoprotein P (SeP) and selenoprotein W. In all these selenoproteins Se is incorporated into the protein molecule via the selenocysteinyltRNA which recognizes the specific UGA codons in mRNA to insert selenocysteine into the primary structure of selenoproteins.

关 键 词：硒 硒蛋白 哺乳动物 

分 类 号：Q581[生物学—生物化学] Q513