人胎儿和新生儿小脑皮质分子层和颗粒层细胞发育的体视学分析  

The stereology analysis of the development of molecular layer cells and granular layer cells in cerebellar cortex of the human fetal and newborn infants

作　　者：符皎荣[1] 吴志虹[2] 何忠平[1] 张彦慧[1] 洪灯[1] 郑小桃[1] 钟南田[1] 蓝永洪[3] 林世珍[3] 

机构地区：[1]海南医学院组织学与胚胎学教研室,海南海口571101 [2]海南医学院解剖学教研室,海南海口571101 [3]海南医学院形态实验室,海南海口571101

出　　处：《海南医学院学报》2009年第6期535-537,共3页Journal of Hainan Medical University

基　　金：海南省教育厅高校科研指导性项目(NO:HJ162007117)~~

摘　　要：目的:探讨人胎儿和新生儿小脑皮质发育的变化规律。方法:应用体视学方法对30例6～10月龄胎儿及6例新生儿小脑皮质分子层细胞、内颗粒层细胞密度、尺寸和分布参数进行观测。结果:小脑皮质分子层细胞的平均体积、平均自由程均逐龄增大,体密度、数密度、表面积密度、核体密度则逐龄减小,但足月胎儿和新生儿期相对恒定;内颗粒层细胞的体密度、数密度、表面积密度、平均体积逐龄增大,核体密度和平均自由程均逐龄减小,7～8月期间变化较明显。结论:胎儿小脑皮质分子层细胞的迁移、增值和分化在出生前、后基本完成,颗粒层细胞出生后仍持续,小脑皮质的发育在7～8月期间是重要时期。Objective： To explore the development of cerebellar cortex of human fetal and newborn infants. Methods： The parameters of density, size and distribution of the molecular and granular layer cells of cerebellar cortex of 30 human fetuses （6 -10 months old ）and 6 newborn infants were studied with stereological methods. Results： The values of mean volumes and mean free path of the molecular layer cells increased while their volume density（Vv）, surface density （Sv） and nucleus-volume density （Vvn, c） decreased as the fetal development, but these indexes were stable for mature fetal and newborn infants. The values of the volume densities, numerical densities, surface densities and mean volumes of the granular layer cells increased while their mean free path and nucleus-volume density decreased as the fetal development, especially during the 7 -8th month. Conclusion ： The transfer, proliferation , differentiation of the cerebellar cortex molecular layer cells were complete before and after the birth; but the transfer, proliferation , differentiation of the cerebellar cortex granular layer cells continued after birth. The important phase for cerebellar cortex development is the 7 -8th month in fetal phase.

关 键 词：小脑皮质 发育 体视学 胎儿 婴儿 新生 

分 类 号：G434[文化科学—教育学] R321[文化科学—教育技术学]